Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature
Authors
Janičić, AleksandarPetrović, Miloš

Zeković, Milica

Vasilić, Nenad
Ćorić, Vesna

Milojević, Bogomir

Živković, Marko
Bumbaširević, Uroš

Review (Published version)
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In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lactate dehydrogenase (LDH)) have an indisputably important role in the management of patients with testicular cancer (TC), the application of these tumor markers may be accompanied with certain limitations, implying the need for additional biomarkers. Contrary to TC, there is a lack of established serological biomarkers for penile cancer (PC) and the management of this urological malignancy is based on multiple clinicopathological parameters. Therefore, the identification and rigorous analytical and clinical validation of reliable biomarkers are considered pivotal for improving PC management. Inflammation may be associated with all stages of oncogenesis, from initial neoplastic transformation to angiogenesis, tissue invasion, and metastasis. Accordingly,... an array of inflammation-related indices have gained increasing attention as emerging predictors of oncological outcomes. The clinical usefulness of systemic inflammation markers was reported in many urological and non-urological malignancies. The aim of this narrative review is to summarize current scientific data regarding the prognostic and predictive significance of systemic inflammation markers in TC and PC patients.
Keywords:
inflammation / penile cancer / prognostic biomarkers / testicular cancerSource:
Life, 2023, 13, 3, 600-Publisher:
- MDPI
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Institut za medicinska istraživanjaTY - JOUR AU - Janičić, Aleksandar AU - Petrović, Miloš AU - Zeković, Milica AU - Vasilić, Nenad AU - Ćorić, Vesna AU - Milojević, Bogomir AU - Živković, Marko AU - Bumbaširević, Uroš PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1285 AB - In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lactate dehydrogenase (LDH)) have an indisputably important role in the management of patients with testicular cancer (TC), the application of these tumor markers may be accompanied with certain limitations, implying the need for additional biomarkers. Contrary to TC, there is a lack of established serological biomarkers for penile cancer (PC) and the management of this urological malignancy is based on multiple clinicopathological parameters. Therefore, the identification and rigorous analytical and clinical validation of reliable biomarkers are considered pivotal for improving PC management. Inflammation may be associated with all stages of oncogenesis, from initial neoplastic transformation to angiogenesis, tissue invasion, and metastasis. Accordingly, an array of inflammation-related indices have gained increasing attention as emerging predictors of oncological outcomes. The clinical usefulness of systemic inflammation markers was reported in many urological and non-urological malignancies. The aim of this narrative review is to summarize current scientific data regarding the prognostic and predictive significance of systemic inflammation markers in TC and PC patients. PB - MDPI T2 - Life T1 - Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature IS - 3 SP - 600 VL - 13 UR - https://hdl.handle.net/21.15107/rcub_rimi_1285 ER -
@article{ author = "Janičić, Aleksandar and Petrović, Miloš and Zeković, Milica and Vasilić, Nenad and Ćorić, Vesna and Milojević, Bogomir and Živković, Marko and Bumbaširević, Uroš", year = "2023", abstract = "In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lactate dehydrogenase (LDH)) have an indisputably important role in the management of patients with testicular cancer (TC), the application of these tumor markers may be accompanied with certain limitations, implying the need for additional biomarkers. Contrary to TC, there is a lack of established serological biomarkers for penile cancer (PC) and the management of this urological malignancy is based on multiple clinicopathological parameters. Therefore, the identification and rigorous analytical and clinical validation of reliable biomarkers are considered pivotal for improving PC management. Inflammation may be associated with all stages of oncogenesis, from initial neoplastic transformation to angiogenesis, tissue invasion, and metastasis. Accordingly, an array of inflammation-related indices have gained increasing attention as emerging predictors of oncological outcomes. The clinical usefulness of systemic inflammation markers was reported in many urological and non-urological malignancies. The aim of this narrative review is to summarize current scientific data regarding the prognostic and predictive significance of systemic inflammation markers in TC and PC patients.", publisher = "MDPI", journal = "Life", title = "Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature", number = "3", pages = "600", volume = "13", url = "https://hdl.handle.net/21.15107/rcub_rimi_1285" }
Janičić, A., Petrović, M., Zeković, M., Vasilić, N., Ćorić, V., Milojević, B., Živković, M.,& Bumbaširević, U.. (2023). Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature. in Life MDPI., 13(3), 600. https://hdl.handle.net/21.15107/rcub_rimi_1285
Janičić A, Petrović M, Zeković M, Vasilić N, Ćorić V, Milojević B, Živković M, Bumbaširević U. Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature. in Life. 2023;13(3):600. https://hdl.handle.net/21.15107/rcub_rimi_1285 .
Janičić, Aleksandar, Petrović, Miloš, Zeković, Milica, Vasilić, Nenad, Ćorić, Vesna, Milojević, Bogomir, Živković, Marko, Bumbaširević, Uroš, "Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature" in Life, 13, no. 3 (2023):600, https://hdl.handle.net/21.15107/rcub_rimi_1285 .