Evolutionary dynamics of Usutu virus: Worldwide dispersal patterns and transmission dynamics in Europe
Autori
Šiljić, MarinaŠehović, Rastko
Janković, Marko
Stamenković, Gorana
Lončar, Ana
Todorović, Marija
Stanojević, Maja
Ćirković, Valentina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background: Usutu virus (USUV) is an emerging mosquito-borne Flavivirus, with birds as the main zoonotic reservoir. Humans are accidental hosts and mostly develop mild or even asymptomatic infections, although severe complications such as encephalitis can also arise. Detailed characterization of the pathogen's phylogenetics may offer valuable insights into the prediction and prevention of potential epidemics; however, lack of uniformity and the number of available USUV sequences worldwide hamper comprehensive investigation. Aim: The study aimed to investigate USUV spatio-temporal dispersal inter- and intracontinentally and to estimate the dynamics of viral spread within Europe. Methods: Phylogeographic and phylodynamic analyses were done using advanced phylogenetic methods implemented in Beast 1.10.4 and Beast 2.6.4 software packages. Results: Herein, we report on a new USUV isolate from Culex pipiens collected in 2019 from Serbia. The results of this research revealed two newly des...cribed intercontinental migration events of USUV from Africa to Germany in the 1970s and from Africa to the Middle East (Israel) in the late 90s. Finally, phylodynamic analysis substantiated the ongoing active expansion of USUV in Europe. Conclusion: The data would imply a high potential for further USUV expansion in Europe. Detailed phylogenetic characterization of the pathogen may offer valuable insights into prediction and prevention of potential epidemics; however, lack of uniformity and number of available USUV sequences worldwide hampers comprehensive investigation. This study draws attention to the need for upscaling USUV surveillance.
Ključne reči:
Usutu virus / phylogeography / phylodynamics / evolutionary dynamic / mosquito vectors / emerging diseaseIzvor:
Frontiers in Microbiology, 2023, 14, 1145981-Izdavač:
- Frontiers Media S.A.
Finansiranje / projekti:
- IN-DEPTH - An Evolutionary Insight Into Molecular Diversity of Emerging Pathogens in Serbia Through Phylogenetic Approach (RS-ScienceFundRS-Promis-6059147)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200110 (Univerzitet u Beogradu, Medicinski fakultet) (RS-MESTD-inst-2020-200110)
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Šiljić, Marina AU - Šehović, Rastko AU - Janković, Marko AU - Stamenković, Gorana AU - Lončar, Ana AU - Todorović, Marija AU - Stanojević, Maja AU - Ćirković, Valentina PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1283 AB - Background: Usutu virus (USUV) is an emerging mosquito-borne Flavivirus, with birds as the main zoonotic reservoir. Humans are accidental hosts and mostly develop mild or even asymptomatic infections, although severe complications such as encephalitis can also arise. Detailed characterization of the pathogen's phylogenetics may offer valuable insights into the prediction and prevention of potential epidemics; however, lack of uniformity and the number of available USUV sequences worldwide hamper comprehensive investigation. Aim: The study aimed to investigate USUV spatio-temporal dispersal inter- and intracontinentally and to estimate the dynamics of viral spread within Europe. Methods: Phylogeographic and phylodynamic analyses were done using advanced phylogenetic methods implemented in Beast 1.10.4 and Beast 2.6.4 software packages. Results: Herein, we report on a new USUV isolate from Culex pipiens collected in 2019 from Serbia. The results of this research revealed two newly described intercontinental migration events of USUV from Africa to Germany in the 1970s and from Africa to the Middle East (Israel) in the late 90s. Finally, phylodynamic analysis substantiated the ongoing active expansion of USUV in Europe. Conclusion: The data would imply a high potential for further USUV expansion in Europe. Detailed phylogenetic characterization of the pathogen may offer valuable insights into prediction and prevention of potential epidemics; however, lack of uniformity and number of available USUV sequences worldwide hampers comprehensive investigation. This study draws attention to the need for upscaling USUV surveillance. PB - Frontiers Media S.A. T2 - Frontiers in Microbiology T1 - Evolutionary dynamics of Usutu virus: Worldwide dispersal patterns and transmission dynamics in Europe SP - 1145981 VL - 14 DO - 10.3389/fmicb.2023.1145981 ER -
@article{ author = "Šiljić, Marina and Šehović, Rastko and Janković, Marko and Stamenković, Gorana and Lončar, Ana and Todorović, Marija and Stanojević, Maja and Ćirković, Valentina", year = "2023", abstract = "Background: Usutu virus (USUV) is an emerging mosquito-borne Flavivirus, with birds as the main zoonotic reservoir. Humans are accidental hosts and mostly develop mild or even asymptomatic infections, although severe complications such as encephalitis can also arise. Detailed characterization of the pathogen's phylogenetics may offer valuable insights into the prediction and prevention of potential epidemics; however, lack of uniformity and the number of available USUV sequences worldwide hamper comprehensive investigation. Aim: The study aimed to investigate USUV spatio-temporal dispersal inter- and intracontinentally and to estimate the dynamics of viral spread within Europe. Methods: Phylogeographic and phylodynamic analyses were done using advanced phylogenetic methods implemented in Beast 1.10.4 and Beast 2.6.4 software packages. Results: Herein, we report on a new USUV isolate from Culex pipiens collected in 2019 from Serbia. The results of this research revealed two newly described intercontinental migration events of USUV from Africa to Germany in the 1970s and from Africa to the Middle East (Israel) in the late 90s. Finally, phylodynamic analysis substantiated the ongoing active expansion of USUV in Europe. Conclusion: The data would imply a high potential for further USUV expansion in Europe. Detailed phylogenetic characterization of the pathogen may offer valuable insights into prediction and prevention of potential epidemics; however, lack of uniformity and number of available USUV sequences worldwide hampers comprehensive investigation. This study draws attention to the need for upscaling USUV surveillance.", publisher = "Frontiers Media S.A.", journal = "Frontiers in Microbiology", title = "Evolutionary dynamics of Usutu virus: Worldwide dispersal patterns and transmission dynamics in Europe", pages = "1145981", volume = "14", doi = "10.3389/fmicb.2023.1145981" }
Šiljić, M., Šehović, R., Janković, M., Stamenković, G., Lončar, A., Todorović, M., Stanojević, M.,& Ćirković, V.. (2023). Evolutionary dynamics of Usutu virus: Worldwide dispersal patterns and transmission dynamics in Europe. in Frontiers in Microbiology Frontiers Media S.A.., 14, 1145981. https://doi.org/10.3389/fmicb.2023.1145981
Šiljić M, Šehović R, Janković M, Stamenković G, Lončar A, Todorović M, Stanojević M, Ćirković V. Evolutionary dynamics of Usutu virus: Worldwide dispersal patterns and transmission dynamics in Europe. in Frontiers in Microbiology. 2023;14:1145981. doi:10.3389/fmicb.2023.1145981 .
Šiljić, Marina, Šehović, Rastko, Janković, Marko, Stamenković, Gorana, Lončar, Ana, Todorović, Marija, Stanojević, Maja, Ćirković, Valentina, "Evolutionary dynamics of Usutu virus: Worldwide dispersal patterns and transmission dynamics in Europe" in Frontiers in Microbiology, 14 (2023):1145981, https://doi.org/10.3389/fmicb.2023.1145981 . .