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Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications

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2023
Alteration_of_Lipid_Metabolism_pub_2023.pdf (722.4Kb)
Authors
Zeković, Milica
Bumbaširević, Uroš
Živković, Marko
Pejčić, Tomislav
Article (Published version)
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Abstract
Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent malignant disease among men worldwide. A single metabolic program cannot epitomize the perplexing reprogramming of tumor metabolism needed to sustain the stemness of neoplastic cells and their prominent energy-consuming functional properties, such as intensive proliferation, uncontrolled growth, migration, and invasion. In cancerous tissue, lipids provide the structural integrity of biological membranes, supply energy, influence the regulation of redox homeostasis, contribute to plasticity, angiogenesis and microenvironment reshaping, mediate the modulation of the inflammatory response, and operate as signaling messengers, i.e., lipid mediators affecting myriad processes relevant for the development of the neoplasia. Comprehensive eluc...idation of the lipid metabolism alterations in PCa, the underlying regulatory mechanisms, and their implications in tumorigenesis and the progression of the disease are gaining growing research interest in the contemporary urologic oncology. Delineation of the unique metabolic signature of the PCa featuring major aberrant pathways including de novo lipogenesis, lipid uptake, storage and compositional reprogramming may provide novel, exciting, and promising avenues for improving diagnosis, risk stratification, and clinical management of such a complex and heterogeneous pathology.

Keywords:
fatty acids / prostate cancer / lipid metabolism / lipogenesis / urologic oncology
Source:
International Journal of Molecular Sciences, 2023, 24, 2, 1391-
Publisher:
  • MDPI
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.3390/ijms24021391

ISSN: 1422-0067

[ Google Scholar ]
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1282
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Zeković, Milica
AU  - Bumbaširević, Uroš
AU  - Živković, Marko
AU  - Pejčić, Tomislav
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1282
AB  - Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent malignant disease among men worldwide. A single metabolic program cannot epitomize the perplexing reprogramming of tumor metabolism needed to sustain the stemness of neoplastic cells and their prominent energy-consuming functional properties, such as intensive proliferation, uncontrolled growth, migration, and invasion. In cancerous tissue, lipids provide the structural integrity of biological membranes, supply energy, influence the regulation of redox homeostasis, contribute to plasticity, angiogenesis and microenvironment reshaping, mediate the modulation of the inflammatory response, and operate as signaling messengers, i.e., lipid mediators affecting myriad processes relevant for the development of the neoplasia. Comprehensive elucidation of the lipid metabolism alterations in PCa, the underlying regulatory mechanisms, and their implications in tumorigenesis and the progression of the disease are gaining growing research interest in the contemporary urologic oncology. Delineation of the unique metabolic signature of the PCa featuring major aberrant pathways including de novo lipogenesis, lipid uptake, storage and compositional reprogramming may provide novel, exciting, and promising avenues for improving diagnosis, risk stratification, and clinical management of such a complex and heterogeneous pathology.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications
IS  - 2
SP  - 1391
VL  - 24
DO  - 10.3390/ijms24021391
ER  - 
@article{
author = "Zeković, Milica and Bumbaširević, Uroš and Živković, Marko and Pejčić, Tomislav",
year = "2023",
abstract = "Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent malignant disease among men worldwide. A single metabolic program cannot epitomize the perplexing reprogramming of tumor metabolism needed to sustain the stemness of neoplastic cells and their prominent energy-consuming functional properties, such as intensive proliferation, uncontrolled growth, migration, and invasion. In cancerous tissue, lipids provide the structural integrity of biological membranes, supply energy, influence the regulation of redox homeostasis, contribute to plasticity, angiogenesis and microenvironment reshaping, mediate the modulation of the inflammatory response, and operate as signaling messengers, i.e., lipid mediators affecting myriad processes relevant for the development of the neoplasia. Comprehensive elucidation of the lipid metabolism alterations in PCa, the underlying regulatory mechanisms, and their implications in tumorigenesis and the progression of the disease are gaining growing research interest in the contemporary urologic oncology. Delineation of the unique metabolic signature of the PCa featuring major aberrant pathways including de novo lipogenesis, lipid uptake, storage and compositional reprogramming may provide novel, exciting, and promising avenues for improving diagnosis, risk stratification, and clinical management of such a complex and heterogeneous pathology.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications",
number = "2",
pages = "1391",
volume = "24",
doi = "10.3390/ijms24021391"
}
Zeković, M., Bumbaširević, U., Živković, M.,& Pejčić, T.. (2023). Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications. in International Journal of Molecular Sciences
MDPI., 24(2), 1391.
https://doi.org/10.3390/ijms24021391
Zeković M, Bumbaširević U, Živković M, Pejčić T. Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications. in International Journal of Molecular Sciences. 2023;24(2):1391.
doi:10.3390/ijms24021391 .
Zeković, Milica, Bumbaširević, Uroš, Živković, Marko, Pejčić, Tomislav, "Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications" in International Journal of Molecular Sciences, 24, no. 2 (2023):1391,
https://doi.org/10.3390/ijms24021391 . .

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