The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer

This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of is...

Кључне речи:

breast cancer / isoflavones / prostate cancer / isoflavones / breast cancer / prostate cancer

Извор:
Antioxidants, 2023, 12, 2, 368-

Издавач:

Multidisciplinary Digital Publishing Institute (MDPI)

Финансирање / пројекти:

DOI: 10.3390/antiox12020368

ISSN: 2076-3921

[ Google Scholar ]

TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Zeković, Milica
AU  - Bumbaširević, Uroš
AU  - Kalaba, Milica
AU  - Vovk, Irena
AU  - Bensa, Maja
AU  - Popović, Lazar
AU  - Tešić, Živoslav
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1278
AB  - This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Antioxidants
T1  - The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer
IS  - 2
SP  - 368
VL  - 12
DO  - 10.3390/antiox12020368
ER  -

@article{
author = "Pejčić, Tomislav and Zeković, Milica and Bumbaširević, Uroš and Kalaba, Milica and Vovk, Irena and Bensa, Maja and Popović, Lazar and Tešić, Živoslav",
year = "2023",
abstract = "This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Antioxidants",
title = "The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer",
number = "2",
pages = "368",
volume = "12",
doi = "10.3390/antiox12020368"
}

Pejčić, T., Zeković, M., Bumbaširević, U., Kalaba, M., Vovk, I., Bensa, M., Popović, L.,& Tešić, Ž.. (2023). The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. in Antioxidants
Multidisciplinary Digital Publishing Institute (MDPI)., 12(2), 368.
https://doi.org/10.3390/antiox12020368

Pejčić T, Zeković M, Bumbaširević U, Kalaba M, Vovk I, Bensa M, Popović L, Tešić Ž. The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. in Antioxidants. 2023;12(2):368.
doi:10.3390/antiox12020368 .

Pejčić, Tomislav, Zeković, Milica, Bumbaširević, Uroš, Kalaba, Milica, Vovk, Irena, Bensa, Maja, Popović, Lazar, Tešić, Živoslav, "The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer" in Antioxidants, 12, no. 2 (2023):368,
https://doi.org/10.3390/antiox12020368 . .