Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability to bind and transport oxygen to the tissues. Besides its ability to transport oxygen, hemoglobin within erythrocytes plays an important role in cellular signaling and modulation of the inflammatory response either directly by binding gas molecules (NO, CO, and CO2) or indirectly by acting as their source. Once hemoglobin reaches the extracellular environment, it acquires several secondary functions affecting surrounding cells and tissues. By modulating the cell functions, this macromolecule becomes involved in the etiology and pathophysiology of various diseases. The up-to-date results disclose the impact of extracellular hemoglobin on (i) redox status, (ii) inflammatory state of cells, (iii) proliferation and chemotaxis, (iv) mitochondrial dynamic, (v) chemoresistance and (vi) differentiation. This review pays special attention to applied biomedical research and the use of non-vertebrate and ...vertebrate extracellular hemoglobin as a promising candidate for hemoglobin-based oxygen carriers, as well as cell culture medium additive. Although recent experimental settings have some limitations, they provide additional insight into the modulatory activity of extracellular hemoglobin in various cellular microenvironments, such as stem or tumor cells niches.
Ključne reči:
extracellular hemoglobin / oxygen carriers / cell culture additives / hemolysis / differentiationIzvor:
Biomolecules, 2022, 12, 11, 1708-Izdavač:
- Multidisciplinary Digital Publishing Institute (MDPI)
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200015 (Univerzitet u Beogradu, Institut za medicinska istraživanja) (RS-MESTD-inst-2020-200015)
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Drvenica, Ivana AU - Stančić, Ana AU - Maslovarić, Irina AU - Trivanović, Drenka AU - Ilić, Vesna PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1274 AB - Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability to bind and transport oxygen to the tissues. Besides its ability to transport oxygen, hemoglobin within erythrocytes plays an important role in cellular signaling and modulation of the inflammatory response either directly by binding gas molecules (NO, CO, and CO2) or indirectly by acting as their source. Once hemoglobin reaches the extracellular environment, it acquires several secondary functions affecting surrounding cells and tissues. By modulating the cell functions, this macromolecule becomes involved in the etiology and pathophysiology of various diseases. The up-to-date results disclose the impact of extracellular hemoglobin on (i) redox status, (ii) inflammatory state of cells, (iii) proliferation and chemotaxis, (iv) mitochondrial dynamic, (v) chemoresistance and (vi) differentiation. This review pays special attention to applied biomedical research and the use of non-vertebrate and vertebrate extracellular hemoglobin as a promising candidate for hemoglobin-based oxygen carriers, as well as cell culture medium additive. Although recent experimental settings have some limitations, they provide additional insight into the modulatory activity of extracellular hemoglobin in various cellular microenvironments, such as stem or tumor cells niches. PB - Multidisciplinary Digital Publishing Institute (MDPI) T2 - Biomolecules T1 - Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects IS - 11 SP - 1708 VL - 12 DO - 10.3390/biom12111708 ER -
@article{ author = "Drvenica, Ivana and Stančić, Ana and Maslovarić, Irina and Trivanović, Drenka and Ilić, Vesna", year = "2022", abstract = "Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability to bind and transport oxygen to the tissues. Besides its ability to transport oxygen, hemoglobin within erythrocytes plays an important role in cellular signaling and modulation of the inflammatory response either directly by binding gas molecules (NO, CO, and CO2) or indirectly by acting as their source. Once hemoglobin reaches the extracellular environment, it acquires several secondary functions affecting surrounding cells and tissues. By modulating the cell functions, this macromolecule becomes involved in the etiology and pathophysiology of various diseases. The up-to-date results disclose the impact of extracellular hemoglobin on (i) redox status, (ii) inflammatory state of cells, (iii) proliferation and chemotaxis, (iv) mitochondrial dynamic, (v) chemoresistance and (vi) differentiation. This review pays special attention to applied biomedical research and the use of non-vertebrate and vertebrate extracellular hemoglobin as a promising candidate for hemoglobin-based oxygen carriers, as well as cell culture medium additive. Although recent experimental settings have some limitations, they provide additional insight into the modulatory activity of extracellular hemoglobin in various cellular microenvironments, such as stem or tumor cells niches.", publisher = "Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Biomolecules", title = "Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects", number = "11", pages = "1708", volume = "12", doi = "10.3390/biom12111708" }
Drvenica, I., Stančić, A., Maslovarić, I., Trivanović, D.,& Ilić, V.. (2022). Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects. in Biomolecules Multidisciplinary Digital Publishing Institute (MDPI)., 12(11), 1708. https://doi.org/10.3390/biom12111708
Drvenica I, Stančić A, Maslovarić I, Trivanović D, Ilić V. Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects. in Biomolecules. 2022;12(11):1708. doi:10.3390/biom12111708 .
Drvenica, Ivana, Stančić, Ana, Maslovarić, Irina, Trivanović, Drenka, Ilić, Vesna, "Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects" in Biomolecules, 12, no. 11 (2022):1708, https://doi.org/10.3390/biom12111708 . .