Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia
Autori
Janjušević, AnaĆirković, Ivana
Minić, Rajna
Stevanović, Goran
Soldatović, Ivan
Mihaljević, Biljana
Vidović, Ana
Marković-Denić, Ljiljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The predictors of intestinal carriage of vancomycin-resistant Enterococcus spp. (VRE) among high-risk patients in the counties of the Southeast Europe Region are insufficiently investigated, yet they could be of key importance in infection control. The aim of the study was to identify risk factors associated with fecal VRE colonization among high-risk inpatients in university hospitals in Serbia. The study comprised 268 inpatients from three university hospitals. Data on patient demographics and clinical characteristics, length of hospital stay, therapy, and procedures were obtained from medical records. Chi-squared tests and univariate and multivariate logistic regressions were performed. Compared to the hemodialysis departments, stay in the geriatric departments, ICUs, and haemato-oncology departments increased the risk for VRE colonization 7.6, 5.4, and 5.5 times, respectively. Compared to inpatients who were hospitalized 48 h before stool sampling for VRE isolation, inpatients hosp...italized 3–7, 8–15, and longer than 16 days before sampling had 5.0-, 4.7-, and 6.6-fold higher risk for VRE colonization, respectively. The use of cephalosporins and fluoroquinolones increased the risk for VRE colonization by 2.2 and 1.9 times, respectively. The age ≥ 65 years increased the risk for VRE colonization 2.3 times. In comparison to the University Clinical Centre of Serbia, the hospital stays at Zemun and Zvezdara University Medical Centres were identified as a protector factors. The obtained results could be valuable in predicting the fecal VRE colonization status at patient admission and consequent implementation of infection control measures targeting at-risk inpatients where VRE screening is not routinely performed.
Ključne reči:
antibiotic-resistance epidemiology / VRE carriage / risk factors / at-risk inpatients / logistic regression / Serbia / Southeast Europe RegionIzvor:
Antibiotics, 2022, 11, 9, 1228-Izdavač:
- Multidisciplinary Digital Publishing Institute (MDPI)
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Janjušević, Ana AU - Ćirković, Ivana AU - Minić, Rajna AU - Stevanović, Goran AU - Soldatović, Ivan AU - Mihaljević, Biljana AU - Vidović, Ana AU - Marković-Denić, Ljiljana PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1260 AB - The predictors of intestinal carriage of vancomycin-resistant Enterococcus spp. (VRE) among high-risk patients in the counties of the Southeast Europe Region are insufficiently investigated, yet they could be of key importance in infection control. The aim of the study was to identify risk factors associated with fecal VRE colonization among high-risk inpatients in university hospitals in Serbia. The study comprised 268 inpatients from three university hospitals. Data on patient demographics and clinical characteristics, length of hospital stay, therapy, and procedures were obtained from medical records. Chi-squared tests and univariate and multivariate logistic regressions were performed. Compared to the hemodialysis departments, stay in the geriatric departments, ICUs, and haemato-oncology departments increased the risk for VRE colonization 7.6, 5.4, and 5.5 times, respectively. Compared to inpatients who were hospitalized 48 h before stool sampling for VRE isolation, inpatients hospitalized 3–7, 8–15, and longer than 16 days before sampling had 5.0-, 4.7-, and 6.6-fold higher risk for VRE colonization, respectively. The use of cephalosporins and fluoroquinolones increased the risk for VRE colonization by 2.2 and 1.9 times, respectively. The age ≥ 65 years increased the risk for VRE colonization 2.3 times. In comparison to the University Clinical Centre of Serbia, the hospital stays at Zemun and Zvezdara University Medical Centres were identified as a protector factors. The obtained results could be valuable in predicting the fecal VRE colonization status at patient admission and consequent implementation of infection control measures targeting at-risk inpatients where VRE screening is not routinely performed. PB - Multidisciplinary Digital Publishing Institute (MDPI) T2 - Antibiotics T1 - Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia IS - 9 SP - 1228 VL - 11 DO - 10.3390/antibiotics11091228 ER -
@article{ author = "Janjušević, Ana and Ćirković, Ivana and Minić, Rajna and Stevanović, Goran and Soldatović, Ivan and Mihaljević, Biljana and Vidović, Ana and Marković-Denić, Ljiljana", year = "2022", abstract = "The predictors of intestinal carriage of vancomycin-resistant Enterococcus spp. (VRE) among high-risk patients in the counties of the Southeast Europe Region are insufficiently investigated, yet they could be of key importance in infection control. The aim of the study was to identify risk factors associated with fecal VRE colonization among high-risk inpatients in university hospitals in Serbia. The study comprised 268 inpatients from three university hospitals. Data on patient demographics and clinical characteristics, length of hospital stay, therapy, and procedures were obtained from medical records. Chi-squared tests and univariate and multivariate logistic regressions were performed. Compared to the hemodialysis departments, stay in the geriatric departments, ICUs, and haemato-oncology departments increased the risk for VRE colonization 7.6, 5.4, and 5.5 times, respectively. Compared to inpatients who were hospitalized 48 h before stool sampling for VRE isolation, inpatients hospitalized 3–7, 8–15, and longer than 16 days before sampling had 5.0-, 4.7-, and 6.6-fold higher risk for VRE colonization, respectively. The use of cephalosporins and fluoroquinolones increased the risk for VRE colonization by 2.2 and 1.9 times, respectively. The age ≥ 65 years increased the risk for VRE colonization 2.3 times. In comparison to the University Clinical Centre of Serbia, the hospital stays at Zemun and Zvezdara University Medical Centres were identified as a protector factors. The obtained results could be valuable in predicting the fecal VRE colonization status at patient admission and consequent implementation of infection control measures targeting at-risk inpatients where VRE screening is not routinely performed.", publisher = "Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Antibiotics", title = "Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia", number = "9", pages = "1228", volume = "11", doi = "10.3390/antibiotics11091228" }
Janjušević, A., Ćirković, I., Minić, R., Stevanović, G., Soldatović, I., Mihaljević, B., Vidović, A.,& Marković-Denić, L.. (2022). Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia. in Antibiotics Multidisciplinary Digital Publishing Institute (MDPI)., 11(9), 1228. https://doi.org/10.3390/antibiotics11091228
Janjušević A, Ćirković I, Minić R, Stevanović G, Soldatović I, Mihaljević B, Vidović A, Marković-Denić L. Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia. in Antibiotics. 2022;11(9):1228. doi:10.3390/antibiotics11091228 .
Janjušević, Ana, Ćirković, Ivana, Minić, Rajna, Stevanović, Goran, Soldatović, Ivan, Mihaljević, Biljana, Vidović, Ana, Marković-Denić, Ljiljana, "Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia" in Antibiotics, 11, no. 9 (2022):1228, https://doi.org/10.3390/antibiotics11091228 . .