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Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors
dc.creator | Dunić, I | |
dc.creator | Đurković-Đaković, Olgica | |
dc.creator | Vesić, S | |
dc.creator | Zerjav, S | |
dc.creator | Jevtović, Đorđe | |
dc.date.accessioned | 2021-04-20T12:09:44Z | |
dc.date.available | 2021-04-20T12:09:44Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0956-4624 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/124 | |
dc.description.abstract | A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P lt 0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P lt 0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration. | en |
dc.publisher | Sage Publications Ltd, London | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Std & Aids | |
dc.subject | herpes zoster (HZ) | en |
dc.subject | AIDS | en |
dc.subject | HAART | en |
dc.subject | immune restoration disease (IRD) | en |
dc.title | Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 478 | |
dc.citation.issue | 7 | |
dc.citation.other | 16(7): 475-478 | |
dc.citation.rank | M23 | |
dc.citation.spage | 475 | |
dc.citation.volume | 16 | |
dc.identifier.doi | 10.1258/0956462054308404 | |
dc.identifier.pmid | 16004625 | |
dc.identifier.scopus | 2-s2.0-22344438346 | |
dc.identifier.wos | 000230673100003 | |
dc.type.version | publishedVersion |
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