Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors
Abstract
A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P lt 0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P lt 0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration.
Keywords:
herpes zoster (HZ) / AIDS / HAART / immune restoration disease (IRD)Source:
International Journal of Std & Aids, 2005, 16, 7, 475-478Publisher:
- Sage Publications Ltd, London
DOI: 10.1258/0956462054308404
ISSN: 0956-4624
PubMed: 16004625
WoS: 000230673100003
Scopus: 2-s2.0-22344438346
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Dunić, I AU - Đurković-Đaković, Olgica AU - Vesić, S AU - Zerjav, S AU - Jevtović, Đorđe PY - 2005 UR - http://rimi.imi.bg.ac.rs/handle/123456789/124 AB - A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P lt 0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P lt 0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration. PB - Sage Publications Ltd, London T2 - International Journal of Std & Aids T1 - Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors EP - 478 IS - 7 SP - 475 VL - 16 DO - 10.1258/0956462054308404 UR - conv_1675 ER -
@article{ author = "Dunić, I and Đurković-Đaković, Olgica and Vesić, S and Zerjav, S and Jevtović, Đorđe", year = "2005", abstract = "A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P lt 0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P lt 0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration.", publisher = "Sage Publications Ltd, London", journal = "International Journal of Std & Aids", title = "Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors", pages = "478-475", number = "7", volume = "16", doi = "10.1258/0956462054308404", url = "conv_1675" }
Dunić, I., Đurković-Đaković, O., Vesić, S., Zerjav, S.,& Jevtović, Đ.. (2005). Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors. in International Journal of Std & Aids Sage Publications Ltd, London., 16(7), 475-478. https://doi.org/10.1258/0956462054308404 conv_1675
Dunić I, Đurković-Đaković O, Vesić S, Zerjav S, Jevtović Đ. Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors. in International Journal of Std & Aids. 2005;16(7):475-478. doi:10.1258/0956462054308404 conv_1675 .
Dunić, I, Đurković-Đaković, Olgica, Vesić, S, Zerjav, S, Jevtović, Đorđe, "Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors" in International Journal of Std & Aids, 16, no. 7 (2005):475-478, https://doi.org/10.1258/0956462054308404 ., conv_1675 .