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Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors

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Authors
Dunić, I
Đurković-Đaković, Olgica
Vesić, S
Zerjav, S
Jevtović, Đorđe
Article (Published version)
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Abstract
A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P lt 0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P lt 0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration.
Keywords:
herpes zoster (HZ) / AIDS / HAART / immune restoration disease (IRD)
Source:
International Journal of Std & Aids, 2005, 16, 7, 475-478
Publisher:
  • Sage Publications Ltd, London

DOI: 10.1258/0956462054308404

ISSN: 0956-4624

PubMed: 16004625

WoS: 000230673100003

Scopus: 2-s2.0-22344438346
[ Google Scholar ]
25
21
URI
http://rimi.imi.bg.ac.rs/handle/123456789/124
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Dunić, I
AU  - Đurković-Đaković, Olgica
AU  - Vesić, S
AU  - Zerjav, S
AU  - Jevtović, Đorđe
PY  - 2005
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/124
AB  - A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P  lt  0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P  lt  0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration.
PB  - Sage Publications Ltd, London
T2  - International Journal of Std & Aids
T1  - Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors
EP  - 478
IS  - 7
SP  - 475
VL  - 16
DO  - 10.1258/0956462054308404
UR  - conv_1675
ER  - 
@article{
author = "Dunić, I and Đurković-Đaković, Olgica and Vesić, S and Zerjav, S and Jevtović, Đorđe",
year = "2005",
abstract = "A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P  lt  0.01) decreased, while the mean CD4 + T-cell counts increased by almost four-fold (P  lt  0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immune response, correlating with the beginning of immune restoration.",
publisher = "Sage Publications Ltd, London",
journal = "International Journal of Std & Aids",
title = "Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors",
pages = "478-475",
number = "7",
volume = "16",
doi = "10.1258/0956462054308404",
url = "conv_1675"
}
Dunić, I., Đurković-Đaković, O., Vesić, S., Zerjav, S.,& Jevtović, Đ.. (2005). Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors. in International Journal of Std & Aids
Sage Publications Ltd, London., 16(7), 475-478.
https://doi.org/10.1258/0956462054308404
conv_1675
Dunić I, Đurković-Đaković O, Vesić S, Zerjav S, Jevtović Đ. Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors. in International Journal of Std & Aids. 2005;16(7):475-478.
doi:10.1258/0956462054308404
conv_1675 .
Dunić, I, Đurković-Đaković, Olgica, Vesić, S, Zerjav, S, Jevtović, Đorđe, "Herpes zoster as an immune restoration disease in AIDS patients during therapy including protease inhibitors" in International Journal of Std & Aids, 16, no. 7 (2005):475-478,
https://doi.org/10.1258/0956462054308404 .,
conv_1675 .

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