Приказ основних података о документу

dc.creatorFilipović, Lidija
dc.creatorKojadinović, Milica
dc.creatorPopović, Milica
dc.date.accessioned2022-02-15T22:29:53Z
dc.date.available2022-02-15T22:29:53Z
dc.date.issued2022
dc.identifier.issn1773-2247
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1204
dc.description.abstractExosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200288/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Drug Delivery Science and Technology
dc.subjectExosomes
dc.subjectExosome-mimetics
dc.subjectDrug delivery
dc.subjectNanocarrier
dc.subjectExosome-based drug delivery
dc.subjectDrug cargo-loading
dc.titleExosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?
dc.typearticle
dc.rights.licenseARR
dc.citation.rankM22~
dc.citation.spage103057
dc.citation.volume68
dc.identifier.doi10.1016/j.jddst.2021.103057
dc.type.versionpublishedVersion


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Приказ основних података о документу