Приказ основних података о документу

dc.creatorĐikić, Dragoslava
dc.creatorBogdanović, Andrija
dc.creatorMarković, Dragana
dc.creatorMitrović-Ajtić, Olivera
dc.creatorSubotički, Tijana
dc.creatorDiklić, Miloš
dc.creatorVukotić, Milica
dc.creatorDragojević, Teodora
dc.creatorŽivković, Emilija
dc.creatorSantibanez, Juan F.
dc.creatorČokić, Vladan
dc.date.accessioned2022-02-15T21:48:33Z
dc.date.available2022-02-15T21:48:33Z
dc.date.issued2022
dc.identifier.issn2218-273X
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1202
dc.description.abstractChronic inflammation is characterized by the production of reactive oxygen species (ROS), reactive nitrogen species, and inflammatory cytokines in myeloproliferative neoplasms (MPNs). In addition to these parameters, the aim of this study was to analyze the influence of ROS on the pro-liferation-related AKT/mTOR signaling pathway and the relationship with inflammatory factors in chronic myelogenous leukemia (CML). The activity of the antioxidant enzymes superoxide dis-mutase, glutathione peroxidase, and catalase is reduced in erythrocytes while levels of the oxidative stress markers malondialdehyde and protein carbonyl are elevated in the plasma of patients with CML. In addition, nitrogen species (nitrotyrosine, iNOS, eNOS) and inflammation markers (IL-6, NFkB, and S100 protein) were increased in granulocytes of CML while anti-inflammatory levels of IL-10 were decreased in plasma. CML granulocytes exhibited greater resistance to cytotoxic H2O2 activity compared to healthy subjects. Moreover, phosphorylation of the apoptotic p53 protein was reduced while the activity of the AKT/mTOR signaling pathway was increased, which was further enhanced by oxidative stress (H2O2) in granulocytes and erythroleukemic K562 cells. IL-6 caused oxidative stress and DNA damage that was mitigated using antioxidant or inhibition of inflammatory NFkB transcription factor in K562 cells. We demonstrated the presence of oxidative and ni-trosative stress in CML, with the former mediated by AKT/mTOR signaling and stimulated by in-flammation.
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBiomolecules
dc.subjectchronic myelogenous leukemia
dc.subjectinflammation
dc.subjectoxidative stress
dc.titleInflammation Promotes Oxidative and Nitrosative Stress in Chronic Myelogenous Leukemia
dc.typearticle
dc.rights.licenseBY
dc.citation.issue2
dc.citation.rankM22~
dc.citation.spage247
dc.citation.volume12
dc.identifier.doi10.3390/biom12020247
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/2634/Inflammation_Promotes_Oxidative_pub_2022.pdf
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу