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dc.creatorJuloski, Jovan
dc.creatorPopović, Tamara B.
dc.creatorDebeljak-Martačić, Jasmina
dc.creatorĆuk, Vladica V.
dc.creatorMilić Perović, Marija S.
dc.creatorStanković, Marija S.
dc.creatorTrbovich, Alexander M.
dc.creatorDe Luka, Silvio R.
dc.date.accessioned2022-02-11T14:50:12Z
dc.date.available2022-02-11T14:50:12Z
dc.date.issued2021
dc.identifier.issn1107-0625
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1201
dc.description.abstractPurpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector and a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content.
dc.publisherZerbinis Medical Publications
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41013/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of BUON
dc.subjectcolorectal cancer
dc.subjectfatty acids
dc.subjecthealthy tissue
dc.subjectAA/EPA ratio
dc.titleFatty acid in colorectal cancer in adult and aged patients of both sexes
dc.typearticleen
dc.typearticle
dc.rights.licenseBY
dc.citation.epage1907
dc.citation.issue5
dc.citation.spage1898
dc.citation.volume26
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/2629/Fatty_acid_in_colorectal_cancer_in_adult_pub_2021.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_rimi_1201
dc.type.versionpublishedVersion


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