Fatty acid in colorectal cancer in adult and aged patients of both sexes
Authors
Juloski, Jovan
Popović, Tamara B.

Debeljak-Martačić, Jasmina

Ćuk, Vladica V.
Milić Perović, Marija S.
Stanković, Marija S.
Trbovich, Alexander M.
De Luka, Silvio R.

Article (Published version)
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Purpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector an...d a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content.
Keywords:
colorectal cancer / fatty acids / healthy tissue / AA/EPA ratioSource:
Journal of BUON, 2021, 26, 5, 1898-1907Publisher:
- Zerbinis Medical Publications
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Institut za medicinska istraživanjaTY - JOUR AU - Juloski, Jovan AU - Popović, Tamara B. AU - Debeljak-Martačić, Jasmina AU - Ćuk, Vladica V. AU - Milić Perović, Marija S. AU - Stanković, Marija S. AU - Trbovich, Alexander M. AU - De Luka, Silvio R. PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1201 AB - Purpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector and a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content. PB - Zerbinis Medical Publications T2 - Journal of BUON T1 - Fatty acid in colorectal cancer in adult and aged patients of both sexes EP - 1907 IS - 5 SP - 1898 VL - 26 UR - https://hdl.handle.net/21.15107/rcub_rimi_1201 ER -
@article{ author = "Juloski, Jovan and Popović, Tamara B. and Debeljak-Martačić, Jasmina and Ćuk, Vladica V. and Milić Perović, Marija S. and Stanković, Marija S. and Trbovich, Alexander M. and De Luka, Silvio R.", year = "2021", abstract = "Purpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector and a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content.", publisher = "Zerbinis Medical Publications", journal = "Journal of BUON", title = "Fatty acid in colorectal cancer in adult and aged patients of both sexes", pages = "1907-1898", number = "5", volume = "26", url = "https://hdl.handle.net/21.15107/rcub_rimi_1201" }
Juloski, J., Popović, T. B., Debeljak-Martačić, J., Ćuk, V. V., Milić Perović, M. S., Stanković, M. S., Trbovich, A. M.,& De Luka, S. R.. (2021). Fatty acid in colorectal cancer in adult and aged patients of both sexes. in Journal of BUON Zerbinis Medical Publications., 26(5), 1898-1907. https://hdl.handle.net/21.15107/rcub_rimi_1201
Juloski J, Popović TB, Debeljak-Martačić J, Ćuk VV, Milić Perović MS, Stanković MS, Trbovich AM, De Luka SR. Fatty acid in colorectal cancer in adult and aged patients of both sexes. in Journal of BUON. 2021;26(5):1898-1907. https://hdl.handle.net/21.15107/rcub_rimi_1201 .
Juloski, Jovan, Popović, Tamara B., Debeljak-Martačić, Jasmina, Ćuk, Vladica V., Milić Perović, Marija S., Stanković, Marija S., Trbovich, Alexander M., De Luka, Silvio R., "Fatty acid in colorectal cancer in adult and aged patients of both sexes" in Journal of BUON, 26, no. 5 (2021):1898-1907, https://hdl.handle.net/21.15107/rcub_rimi_1201 .