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Fatty acid in colorectal cancer in adult and aged patients of both sexes

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2021
Fatty_acid_in_colorectal_cancer_in_adult_pub_2021.pdf (916.5Kb)
Authors
Juloski, Jovan
Popović, Tamara B.
Debeljak-Martačić, Jasmina
Ćuk, Vladica V.
Milić Perović, Marija S.
Stanković, Marija S.
Trbovich, Alexander M.
De Luka, Silvio R.
Article (Published version)
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Abstract
Purpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector an...d a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content.

Keywords:
colorectal cancer / fatty acids / healthy tissue / AA/EPA ratio
Source:
Journal of BUON, 2021, 26, 5, 1898-1907
Publisher:
  • Zerbinis Medical Publications
Funding / projects:
  • Hypothalamic and medullary functional genomics in stress-induced hypertension (RS-41013)

ISSN: 1107-0625

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_rimi_1201
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1201
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Juloski, Jovan
AU  - Popović, Tamara B.
AU  - Debeljak-Martačić, Jasmina
AU  - Ćuk, Vladica V.
AU  - Milić Perović, Marija S.
AU  - Stanković, Marija S.
AU  - Trbovich, Alexander M.
AU  - De Luka, Silvio R.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1201
AB  - Purpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector and a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content.
PB  - Zerbinis Medical Publications
T2  - Journal of BUON
T1  - Fatty acid in colorectal cancer in adult and aged patients of both sexes
EP  - 1907
IS  - 5
SP  - 1898
VL  - 26
ER  - 
@article{
author = "Juloski, Jovan and Popović, Tamara B. and Debeljak-Martačić, Jasmina and Ćuk, Vladica V. and Milić Perović, Marija S. and Stanković, Marija S. and Trbovich, Alexander M. and De Luka, Silvio R.",
year = "2021",
abstract = "Purpose: Colorectal cancer represents the second most common type of cancer in Serbia. Alteration of lipid metabolism begins early, and can represent a central hallmark in cancer evolution. Fatty acids have various important functions as building components of cell membranes, as signaling molecules in immune responses and also manage the general cancer signaling network. The purpose of this study was to investigate the difference of various fatty acids content between colorectal cancer and adjacent healthy intestinal tissue in adult and aged patients of both sexes. Methods: 52 subjects participated in this study. Healthy colon mucosa and tumor tissue samples were obtained from patients previously diagnosed with colorectal carcinoma. Simplified method of Berstad et al was used for direct transesterification of total lipids in tumor and healthy mucosa tissue samples and separations of the methyl esters was carried out using a gas chromatograph equipped with a split/ splitless injector and a flame ionization detector. Results: 18 0, 18 1 n7, 20 3, 20 4, 20 5, 22 4, 22 5 22 6, SFA, PUFA, n6, n3 and AA/EPA were significantly higher in tumor tissue. On the other hand, 18 1 n9, 18 2, 18 3 n3, MUFA, n6/ n3 were significantly higher in healthy tissue. Conclusions: Saturation index (SI) could be a valuable tool to delineate robust immune response and worse prognosis in patients with colorectal cancer. Our study demonstrated significant differences in fatty acid profiles between tumor tissue and healthy mucosa. Parameters, such as gender, age, stage and mucinous component didn't influence altered fatty acid content.",
publisher = "Zerbinis Medical Publications",
journal = "Journal of BUON",
title = "Fatty acid in colorectal cancer in adult and aged patients of both sexes",
pages = "1907-1898",
number = "5",
volume = "26"
}
Juloski, J., Popović, T. B., Debeljak-Martačić, J., Ćuk, V. V., Milić Perović, M. S., Stanković, M. S., Trbovich, A. M.,& De Luka, S. R.. (2021). Fatty acid in colorectal cancer in adult and aged patients of both sexes. in Journal of BUON
Zerbinis Medical Publications., 26(5), 1898-1907.
Juloski J, Popović TB, Debeljak-Martačić J, Ćuk VV, Milić Perović MS, Stanković MS, Trbovich AM, De Luka SR. Fatty acid in colorectal cancer in adult and aged patients of both sexes. in Journal of BUON. 2021;26(5):1898-1907..
Juloski, Jovan, Popović, Tamara B., Debeljak-Martačić, Jasmina, Ćuk, Vladica V., Milić Perović, Marija S., Stanković, Marija S., Trbovich, Alexander M., De Luka, Silvio R., "Fatty acid in colorectal cancer in adult and aged patients of both sexes" in Journal of BUON, 26, no. 5 (2021):1898-1907.

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