Postnatal ocular toxoplasmosis in immunocompetent patients
Authors
Lijeskić, Olivera
Štajner, Tijana

Srbljanović, Jelena

Radosavljević, Aleksandra

Bobić, Branko

Klun, Ivana

Stanojević-Paović, Anka
Đurković-Đaković, Olgica

Article (Published version)
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Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of ina...ctive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.
Keywords:
Toxoplasma gondii / ocular toxoplasmosis / postnatal infection / immunocompetent patients / strain genotypeSource:
The Journal of Infection in Developing Countries, 2021, 15, 10, 1515-1522Funding / projects:
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Institut za medicinska istraživanjaTY - JOUR AU - Lijeskić, Olivera AU - Štajner, Tijana AU - Srbljanović, Jelena AU - Radosavljević, Aleksandra AU - Bobić, Branko AU - Klun, Ivana AU - Stanojević-Paović, Anka AU - Đurković-Đaković, Olgica PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1198 AB - Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of inactive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches. T2 - The Journal of Infection in Developing Countries T1 - Postnatal ocular toxoplasmosis in immunocompetent patients EP - 1522 IS - 10 SP - 1515 VL - 15 DO - 10.3855/jidc.14824 ER -
@article{ author = "Lijeskić, Olivera and Štajner, Tijana and Srbljanović, Jelena and Radosavljević, Aleksandra and Bobić, Branko and Klun, Ivana and Stanojević-Paović, Anka and Đurković-Đaković, Olgica", year = "2021", abstract = "Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of inactive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.", journal = "The Journal of Infection in Developing Countries", title = "Postnatal ocular toxoplasmosis in immunocompetent patients", pages = "1522-1515", number = "10", volume = "15", doi = "10.3855/jidc.14824" }
Lijeskić, O., Štajner, T., Srbljanović, J., Radosavljević, A., Bobić, B., Klun, I., Stanojević-Paović, A.,& Đurković-Đaković, O.. (2021). Postnatal ocular toxoplasmosis in immunocompetent patients. in The Journal of Infection in Developing Countries, 15(10), 1515-1522. https://doi.org/10.3855/jidc.14824
Lijeskić O, Štajner T, Srbljanović J, Radosavljević A, Bobić B, Klun I, Stanojević-Paović A, Đurković-Đaković O. Postnatal ocular toxoplasmosis in immunocompetent patients. in The Journal of Infection in Developing Countries. 2021;15(10):1515-1522. doi:10.3855/jidc.14824 .
Lijeskić, Olivera, Štajner, Tijana, Srbljanović, Jelena, Radosavljević, Aleksandra, Bobić, Branko, Klun, Ivana, Stanojević-Paović, Anka, Đurković-Đaković, Olgica, "Postnatal ocular toxoplasmosis in immunocompetent patients" in The Journal of Infection in Developing Countries, 15, no. 10 (2021):1515-1522, https://doi.org/10.3855/jidc.14824 . .