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Postnatal ocular toxoplasmosis in immunocompetent patients

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2021
Postnatal_ocular_toxoplasmosis_in_mmunocompetent_patients_pub_2021.pdf (438.9Kb)
Authors
Lijeskić, Olivera
Štajner, Tijana
Srbljanović, Jelena
Radosavljević, Aleksandra
Bobić, Branko
Klun, Ivana
Stanojević-Paović, Anka
Đurković-Đaković, Olgica
Article (Published version)
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Abstract
Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of ina...ctive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.

Keywords:
Toxoplasma gondii / ocular toxoplasmosis / postnatal infection / immunocompetent patients / strain genotype
Source:
The Journal of Infection in Developing Countries, 2021, 15, 10, 1515-1522
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.3855/jidc.14824

ISSN: 1972-2680

[ Google Scholar ]
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1198
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Lijeskić, Olivera
AU  - Štajner, Tijana
AU  - Srbljanović, Jelena
AU  - Radosavljević, Aleksandra
AU  - Bobić, Branko
AU  - Klun, Ivana
AU  - Stanojević-Paović, Anka
AU  - Đurković-Đaković, Olgica
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1198
AB  - Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of inactive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.
T2  - The Journal of Infection in Developing Countries
T1  - Postnatal ocular toxoplasmosis in immunocompetent patients
EP  - 1522
IS  - 10
SP  - 1515
VL  - 15
DO  - 10.3855/jidc.14824
ER  - 
@article{
author = "Lijeskić, Olivera and Štajner, Tijana and Srbljanović, Jelena and Radosavljević, Aleksandra and Bobić, Branko and Klun, Ivana and Stanojević-Paović, Anka and Đurković-Đaković, Olgica",
year = "2021",
abstract = "Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of inactive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.",
journal = "The Journal of Infection in Developing Countries",
title = "Postnatal ocular toxoplasmosis in immunocompetent patients",
pages = "1522-1515",
number = "10",
volume = "15",
doi = "10.3855/jidc.14824"
}
Lijeskić, O., Štajner, T., Srbljanović, J., Radosavljević, A., Bobić, B., Klun, I., Stanojević-Paović, A.,& Đurković-Đaković, O.. (2021). Postnatal ocular toxoplasmosis in immunocompetent patients. in The Journal of Infection in Developing Countries, 15(10), 1515-1522.
https://doi.org/10.3855/jidc.14824
Lijeskić O, Štajner T, Srbljanović J, Radosavljević A, Bobić B, Klun I, Stanojević-Paović A, Đurković-Đaković O. Postnatal ocular toxoplasmosis in immunocompetent patients. in The Journal of Infection in Developing Countries. 2021;15(10):1515-1522.
doi:10.3855/jidc.14824 .
Lijeskić, Olivera, Štajner, Tijana, Srbljanović, Jelena, Radosavljević, Aleksandra, Bobić, Branko, Klun, Ivana, Stanojević-Paović, Anka, Đurković-Đaković, Olgica, "Postnatal ocular toxoplasmosis in immunocompetent patients" in The Journal of Infection in Developing Countries, 15, no. 10 (2021):1515-1522,
https://doi.org/10.3855/jidc.14824 . .

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