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dc.creatorDakić, Tamara
dc.creatorLakić, Iva
dc.creatorZec, Manja
dc.creatorTakić, Marija
dc.creatorStojiljković, Mojca
dc.creatorJevđović, Tanja
dc.date.accessioned2022-02-09T11:52:41Z
dc.date.available2022-02-09T11:52:41Z
dc.date.issued2021
dc.identifier.issn0022-5142
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1197
dc.description.abstractBACKGROUND: Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS: Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION: Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder.
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of the Science of Food and Agriculture
dc.subjectfructose
dc.subjectglucose transporters
dc.subjecthippocampus
dc.subjecthypothalamus
dc.subjectwalnut
dc.titleFructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression
dc.typearticle
dc.rights.licenseARR
dc.citation.epage5991
dc.citation.issue14
dc.citation.spage5984
dc.citation.volume101
dc.identifier.doi10.1002/jsfa.11252
dc.type.versionpublishedVersion


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Приказ основних података о документу