Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
Authors
Mojsilović, SlavkoJauković, Aleksandra
Kukolj, Tamara
Obradović, Hristina
Okić Đorđević, Ivana
Petrović, Anđelija
Bugarski, Diana
Article (Published version)
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As an organism ages, many physiological processes change, including the immune system. This process, called immunosenescence, characterized by abnormal activation and imbalance of innate and adaptive immunity, leads to a state of chronic low-grade systemic inflammation, termed inflammaging. Aging and inflammaging are considered to be the root of many diseases of the elderly, as infections, autoimmune and chronic inflammatory diseases, degenerative diseases, and cancer. The role of mesenchymal stromal/stem cells (MSCs) in the inflammaging process and the age-related diseases is not completely established, although numerous features of aging MSCs, including altered immunomodulatory properties, impeded MSC niche supporting functions, and senescent MSC secretory repertoire are consistent with inflammaging development. Although senescence has its physiological function and can represent a mechanism of tumor prevention, in most cases it eventually transforms into a deleterious (para-)inflamm...atory process that promotes tumor growth. In this review we are going through current literature, trying to explore the role of senescent MSCs in making and/or sustaining a microenvironment permissive to tumor development and to analyze the therapeutic options that could target this process.
Keywords:
tumor / senescence / inflammaging / mesenchymal stromal/stem cells / microenvironmentSource:
Journal of Personalized Medicine, 2021, 11, 11, 1133-Publisher:
- Multidisciplinary Digital Publishing Institute (MDPI)
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-MESTD-inst-2020-200015)
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Institut za medicinska istraživanjaTY - JOUR AU - Mojsilović, Slavko AU - Jauković, Aleksandra AU - Kukolj, Tamara AU - Obradović, Hristina AU - Okić Đorđević, Ivana AU - Petrović, Anđelija AU - Bugarski, Diana PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1175 AB - As an organism ages, many physiological processes change, including the immune system. This process, called immunosenescence, characterized by abnormal activation and imbalance of innate and adaptive immunity, leads to a state of chronic low-grade systemic inflammation, termed inflammaging. Aging and inflammaging are considered to be the root of many diseases of the elderly, as infections, autoimmune and chronic inflammatory diseases, degenerative diseases, and cancer. The role of mesenchymal stromal/stem cells (MSCs) in the inflammaging process and the age-related diseases is not completely established, although numerous features of aging MSCs, including altered immunomodulatory properties, impeded MSC niche supporting functions, and senescent MSC secretory repertoire are consistent with inflammaging development. Although senescence has its physiological function and can represent a mechanism of tumor prevention, in most cases it eventually transforms into a deleterious (para-)inflammatory process that promotes tumor growth. In this review we are going through current literature, trying to explore the role of senescent MSCs in making and/or sustaining a microenvironment permissive to tumor development and to analyze the therapeutic options that could target this process. PB - Multidisciplinary Digital Publishing Institute (MDPI) T2 - Journal of Personalized Medicine T1 - Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy IS - 11 SP - 1133 VL - 11 DO - 10.3390/jpm11111133 ER -
@article{ author = "Mojsilović, Slavko and Jauković, Aleksandra and Kukolj, Tamara and Obradović, Hristina and Okić Đorđević, Ivana and Petrović, Anđelija and Bugarski, Diana", year = "2021", abstract = "As an organism ages, many physiological processes change, including the immune system. This process, called immunosenescence, characterized by abnormal activation and imbalance of innate and adaptive immunity, leads to a state of chronic low-grade systemic inflammation, termed inflammaging. Aging and inflammaging are considered to be the root of many diseases of the elderly, as infections, autoimmune and chronic inflammatory diseases, degenerative diseases, and cancer. The role of mesenchymal stromal/stem cells (MSCs) in the inflammaging process and the age-related diseases is not completely established, although numerous features of aging MSCs, including altered immunomodulatory properties, impeded MSC niche supporting functions, and senescent MSC secretory repertoire are consistent with inflammaging development. Although senescence has its physiological function and can represent a mechanism of tumor prevention, in most cases it eventually transforms into a deleterious (para-)inflammatory process that promotes tumor growth. In this review we are going through current literature, trying to explore the role of senescent MSCs in making and/or sustaining a microenvironment permissive to tumor development and to analyze the therapeutic options that could target this process.", publisher = "Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Journal of Personalized Medicine", title = "Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy", number = "11", pages = "1133", volume = "11", doi = "10.3390/jpm11111133" }
Mojsilović, S., Jauković, A., Kukolj, T., Obradović, H., Okić Đorđević, I., Petrović, A.,& Bugarski, D.. (2021). Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy. in Journal of Personalized Medicine Multidisciplinary Digital Publishing Institute (MDPI)., 11(11), 1133. https://doi.org/10.3390/jpm11111133
Mojsilović S, Jauković A, Kukolj T, Obradović H, Okić Đorđević I, Petrović A, Bugarski D. Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy. in Journal of Personalized Medicine. 2021;11(11):1133. doi:10.3390/jpm11111133 .
Mojsilović, Slavko, Jauković, Aleksandra, Kukolj, Tamara, Obradović, Hristina, Okić Đorđević, Ivana, Petrović, Anđelija, Bugarski, Diana, "Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy" in Journal of Personalized Medicine, 11, no. 11 (2021):1133, https://doi.org/10.3390/jpm11111133 . .