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Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition

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2021
Liver_Disease_and_COVID19_pub_2021.pdf (1.434Mb)
Autori
Ristić-Medić, Danijela K.
Petrović, Snježana
Arsić, Aleksandra
Vučić, Vesna M.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evi...dence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.

Ključne reči:
COVID-19 / Liver injury / Nutrients / SARS-CoV-2 / Treatment
Izvor:
World Journal of Gastroenterology, 2021, 27, 34, 5682-5699
Izdavač:
  • Baishideng Publishing Group
Finansiranje / projekti:
  • Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 200015 (Univerzitet u Beogradu, Institut za medicinska istraživanja) (RS-200015)

DOI: 10.3748/wjg.v27.i34.5682

ISSN: 1007-9327

[ Google Scholar ]
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1166
Kolekcije
  • Radovi istraživača / Researchers' publications
Institucija/grupa
Institut za medicinska istraživanja
TY  - JOUR
AU  - Ristić-Medić, Danijela K.
AU  - Petrović, Snježana
AU  - Arsić, Aleksandra
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1166
AB  - Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.
PB  - Baishideng Publishing Group
T2  - World Journal of Gastroenterology
T1  - Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition
EP  - 5699
IS  - 34
SP  - 5682
VL  - 27
DO  - 10.3748/wjg.v27.i34.5682
ER  - 
@article{
author = "Ristić-Medić, Danijela K. and Petrović, Snježana and Arsić, Aleksandra and Vučić, Vesna M.",
year = "2021",
abstract = "Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.",
publisher = "Baishideng Publishing Group",
journal = "World Journal of Gastroenterology",
title = "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition",
pages = "5699-5682",
number = "34",
volume = "27",
doi = "10.3748/wjg.v27.i34.5682"
}
Ristić-Medić, D. K., Petrović, S., Arsić, A.,& Vučić, V. M.. (2021). Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology
Baishideng Publishing Group., 27(34), 5682-5699.
https://doi.org/10.3748/wjg.v27.i34.5682
Ristić-Medić DK, Petrović S, Arsić A, Vučić VM. Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology. 2021;27(34):5682-5699.
doi:10.3748/wjg.v27.i34.5682 .
Ristić-Medić, Danijela K., Petrović, Snježana, Arsić, Aleksandra, Vučić, Vesna M., "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition" in World Journal of Gastroenterology, 27, no. 34 (2021):5682-5699,
https://doi.org/10.3748/wjg.v27.i34.5682 . .

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