Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice
Аутори
Milenković, DraganKrga, Irena
Dinel, Anne-Laure
Morand, Christine
Laye, Sophie
Castanon, Nathalie
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Dietary anthocyanins may slow cognitive decline, improve cognitive performance and exert neuroprotective effects against neurodegenerative disorders. However, the underlying mechanisms of their action are not fully understood. This study investigated the effects of 12-week anthocyanin-rich bilberry extract supplementation (0.02%) on global gene expression in the hippocampus of ApoE-/- mice to help the understanding of molecular mechanisms underlying anthocyanin neuroprotective effects. Gene expression analysis identified 1698 differently expressed genes, with 611 downregulated and 1087 upregulated genes. Bioinformatics revealed that these genes regulate different biological processes, including neurogenesis, inflammation, metabolism, cell to cell adhesion, cytoskeleton organization, and Alzheimer's and Parkinson's disease pathology. The bioinformatic analysis also proposed potential miRNAs and transcription factors that could be involved in the mediation of these nutrigenomic effects. ...Results from molecular docking also suggested that anthocyanins could bind to top transcription factors with, as potential consequence, an impact on their gene expression regulation. Taken together, integrated analysis revealed a multi-target mode of action of anthocyanin-rich bilberry extract in the hippocampus underlying their neuroprotective properties.
Кључне речи:
Anthocyanins / ApoE mice / Bilberry extract / Hippocampus / NutrigenomicsИзвор:
Journal of Functional Foods, 2021, 85, 104609-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Milenković, Dragan AU - Krga, Irena AU - Dinel, Anne-Laure AU - Morand, Christine AU - Laye, Sophie AU - Castanon, Nathalie PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1146 AB - Dietary anthocyanins may slow cognitive decline, improve cognitive performance and exert neuroprotective effects against neurodegenerative disorders. However, the underlying mechanisms of their action are not fully understood. This study investigated the effects of 12-week anthocyanin-rich bilberry extract supplementation (0.02%) on global gene expression in the hippocampus of ApoE-/- mice to help the understanding of molecular mechanisms underlying anthocyanin neuroprotective effects. Gene expression analysis identified 1698 differently expressed genes, with 611 downregulated and 1087 upregulated genes. Bioinformatics revealed that these genes regulate different biological processes, including neurogenesis, inflammation, metabolism, cell to cell adhesion, cytoskeleton organization, and Alzheimer's and Parkinson's disease pathology. The bioinformatic analysis also proposed potential miRNAs and transcription factors that could be involved in the mediation of these nutrigenomic effects. Results from molecular docking also suggested that anthocyanins could bind to top transcription factors with, as potential consequence, an impact on their gene expression regulation. Taken together, integrated analysis revealed a multi-target mode of action of anthocyanin-rich bilberry extract in the hippocampus underlying their neuroprotective properties. PB - Elsevier T2 - Journal of Functional Foods T1 - Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice SP - 104609 VL - 85 DO - 10.1016/j.jff.2021.104609 ER -
@article{ author = "Milenković, Dragan and Krga, Irena and Dinel, Anne-Laure and Morand, Christine and Laye, Sophie and Castanon, Nathalie", year = "2021", abstract = "Dietary anthocyanins may slow cognitive decline, improve cognitive performance and exert neuroprotective effects against neurodegenerative disorders. However, the underlying mechanisms of their action are not fully understood. This study investigated the effects of 12-week anthocyanin-rich bilberry extract supplementation (0.02%) on global gene expression in the hippocampus of ApoE-/- mice to help the understanding of molecular mechanisms underlying anthocyanin neuroprotective effects. Gene expression analysis identified 1698 differently expressed genes, with 611 downregulated and 1087 upregulated genes. Bioinformatics revealed that these genes regulate different biological processes, including neurogenesis, inflammation, metabolism, cell to cell adhesion, cytoskeleton organization, and Alzheimer's and Parkinson's disease pathology. The bioinformatic analysis also proposed potential miRNAs and transcription factors that could be involved in the mediation of these nutrigenomic effects. Results from molecular docking also suggested that anthocyanins could bind to top transcription factors with, as potential consequence, an impact on their gene expression regulation. Taken together, integrated analysis revealed a multi-target mode of action of anthocyanin-rich bilberry extract in the hippocampus underlying their neuroprotective properties.", publisher = "Elsevier", journal = "Journal of Functional Foods", title = "Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice", pages = "104609", volume = "85", doi = "10.1016/j.jff.2021.104609" }
Milenković, D., Krga, I., Dinel, A., Morand, C., Laye, S.,& Castanon, N.. (2021). Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice. in Journal of Functional Foods Elsevier., 85, 104609. https://doi.org/10.1016/j.jff.2021.104609
Milenković D, Krga I, Dinel A, Morand C, Laye S, Castanon N. Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice. in Journal of Functional Foods. 2021;85:104609. doi:10.1016/j.jff.2021.104609 .
Milenković, Dragan, Krga, Irena, Dinel, Anne-Laure, Morand, Christine, Laye, Sophie, Castanon, Nathalie, "Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice" in Journal of Functional Foods, 85 (2021):104609, https://doi.org/10.1016/j.jff.2021.104609 . .