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Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

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2021
Resveratrol_protects_cardiac_pub_2021.pdf (12.55Mb)
Authors
Grujić-Milanović, Jelica
Jaćević, Vesna
Miloradović, Zoran
Jovović, Đurđica
Milosavljević, Ivica
Milanović, Slađan
Mihailović-Stanojević, Nevena
Article (Published version)
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Abstract
Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after re...sveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.

Keywords:
heart / resveratrol / spontaneously and malignant hypertension
Source:
International Journal of Molecular Sciences, 2021, 22, 9, 5006-
Publisher:
  • MDPI
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.3390/ijms22095006

ISSN: 1661-6596

WoS: 000650370100001

[ Google Scholar ]
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1137
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Grujić-Milanović, Jelica
AU  - Jaćević, Vesna
AU  - Miloradović, Zoran
AU  - Jovović, Đurđica
AU  - Milosavljević, Ivica
AU  - Milanović, Slađan
AU  - Mihailović-Stanojević, Nevena
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1137
AB  - Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties
IS  - 9
SP  - 5006
VL  - 22
DO  - 10.3390/ijms22095006
ER  - 
@article{
author = "Grujić-Milanović, Jelica and Jaćević, Vesna and Miloradović, Zoran and Jovović, Đurđica and Milosavljević, Ivica and Milanović, Slađan and Mihailović-Stanojević, Nevena",
year = "2021",
abstract = "Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties",
number = "9",
pages = "5006",
volume = "22",
doi = "10.3390/ijms22095006"
}
Grujić-Milanović, J., Jaćević, V., Miloradović, Z., Jovović, Đ., Milosavljević, I., Milanović, S.,& Mihailović-Stanojević, N.. (2021). Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. in International Journal of Molecular Sciences
MDPI., 22(9), 5006.
https://doi.org/10.3390/ijms22095006
Grujić-Milanović J, Jaćević V, Miloradović Z, Jovović Đ, Milosavljević I, Milanović S, Mihailović-Stanojević N. Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. in International Journal of Molecular Sciences. 2021;22(9):5006.
doi:10.3390/ijms22095006 .
Grujić-Milanović, Jelica, Jaćević, Vesna, Miloradović, Zoran, Jovović, Đurđica, Milosavljević, Ivica, Milanović, Slađan, Mihailović-Stanojević, Nevena, "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties" in International Journal of Molecular Sciences, 22, no. 9 (2021):5006,
https://doi.org/10.3390/ijms22095006 . .

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