Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties
Authors
Grujić-Milanović, Jelica
Jaćević, Vesna

Miloradović, Zoran

Jovović, Đurđica

Milosavljević, Ivica
Milanović, Slađan

Mihailović-Stanojević, Nevena

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Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after re...sveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.
Keywords:
heart / resveratrol / spontaneously and malignant hypertensionSource:
International Journal of Molecular Sciences, 2021, 22, 9, 5006-Publisher:
- MDPI
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Institut za medicinska istraživanjaTY - JOUR AU - Grujić-Milanović, Jelica AU - Jaćević, Vesna AU - Miloradović, Zoran AU - Jovović, Đurđica AU - Milosavljević, Ivica AU - Milanović, Slađan AU - Mihailović-Stanojević, Nevena PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1137 AB - Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension. PB - MDPI T2 - International Journal of Molecular Sciences T1 - Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties IS - 9 SP - 5006 VL - 22 DO - 10.3390/ijms22095006 ER -
@article{ author = "Grujić-Milanović, Jelica and Jaćević, Vesna and Miloradović, Zoran and Jovović, Đurđica and Milosavljević, Ivica and Milanović, Slađan and Mihailović-Stanojević, Nevena", year = "2021", abstract = "Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties", number = "9", pages = "5006", volume = "22", doi = "10.3390/ijms22095006" }
Grujić-Milanović, J., Jaćević, V., Miloradović, Z., Jovović, Đ., Milosavljević, I., Milanović, S.,& Mihailović-Stanojević, N.. (2021). Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. in International Journal of Molecular Sciences MDPI., 22(9), 5006. https://doi.org/10.3390/ijms22095006
Grujić-Milanović J, Jaćević V, Miloradović Z, Jovović Đ, Milosavljević I, Milanović S, Mihailović-Stanojević N. Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. in International Journal of Molecular Sciences. 2021;22(9):5006. doi:10.3390/ijms22095006 .
Grujić-Milanović, Jelica, Jaćević, Vesna, Miloradović, Zoran, Jovović, Đurđica, Milosavljević, Ivica, Milanović, Slađan, Mihailović-Stanojević, Nevena, "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties" in International Journal of Molecular Sciences, 22, no. 9 (2021):5006, https://doi.org/10.3390/ijms22095006 . .