Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage.
TY - JOUR
AU - Grujić-Milanović, Jelica
AU - Miloradović, Zoran
AU - Mihailović-Stanojević, Nevena
AU - Banjac, Vojislav V.
AU - Vidosavljević, Strahinja
AU - Ivanov, Milan
AU - Karanović, Danijela
AU - Vajić, Una-Jovana
AU - Jovović, Đurđica
PY - 2021
UR - http://rimi.imi.bg.ac.rs/handle/123456789/1132
AB - Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage.
PB - Elsevier
T2 - Biomedicine & Pharmacotherapy
T1 - Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats
SP - 111691
VL - 139
DO - 10.1016/j.biopha.2021.111691
ER -
@article{
author = "Grujić-Milanović, Jelica and Miloradović, Zoran and Mihailović-Stanojević, Nevena and Banjac, Vojislav V. and Vidosavljević, Strahinja and Ivanov, Milan and Karanović, Danijela and Vajić, Una-Jovana and Jovović, Đurđica",
year = "2021",
abstract = "Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage.",
publisher = "Elsevier",
journal = "Biomedicine & Pharmacotherapy",
title = "Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats",
pages = "111691",
volume = "139",
doi = "10.1016/j.biopha.2021.111691"
}
Grujić-Milanović, J., Miloradović, Z., Mihailović-Stanojević, N., Banjac, V. V., Vidosavljević, S., Ivanov, M., Karanović, D., Vajić, U.,& Jovović, Đ.. (2021). Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats. in Biomedicine & Pharmacotherapy
Elsevier., 139, 111691.
https://doi.org/10.1016/j.biopha.2021.111691
Grujić-Milanović J, Miloradović Z, Mihailović-Stanojević N, Banjac VV, Vidosavljević S, Ivanov M, Karanović D, Vajić U, Jovović Đ. Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats. in Biomedicine & Pharmacotherapy. 2021;139:111691.
doi:10.1016/j.biopha.2021.111691 .
Grujić-Milanović, Jelica, Miloradović, Zoran, Mihailović-Stanojević, Nevena, Banjac, Vojislav V., Vidosavljević, Strahinja, Ivanov, Milan, Karanović, Danijela, Vajić, Una-Jovana, Jovović, Đurđica, "Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats" in Biomedicine & Pharmacotherapy, 139 (2021):111691,
https://doi.org/10.1016/j.biopha.2021.111691 . .
