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dc.creatorGrujić, Jelica
dc.creatorĐurković-Đaković, Olgica
dc.creatorNikolić, A.
dc.creatorKlun, Ivana
dc.creatorBobić, Branko
dc.date.accessioned2021-04-20T12:08:54Z
dc.date.available2021-04-20T12:08:54Z
dc.date.issued2005
dc.identifier.issn0924-8579
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/111
dc.description.abstractThe antitoxoplasmic activity of spiramycin (SPI) was evaluated in murine models of infection using a type-1 (RH) or type-2 (Me49) strain of Toxoplasma gondii. In mice infected with 10(2) tachyzoites of the RH strain, treatment with 100 and 200 mg SPI/kg/day had only a limited effect; despite some dose-dependent prolongation of survival, it was unable to protect mice against death. In contrast, in acute infection induced by peroral inoculation of 10, but not 20, cysts of the Me49 strain, a 3-week course of 100 mg SPI/kg/day and a 4-week course of 200 mg/kg/day significantly enhanced protection and markedly reduced brain cyst burdens at 6 months post infection (p.i.). In chronic infection established by inoculation of 10 cysts 3 months previously, a 3-week course of 200 mg SPI/kg/day resulted in significantly decreased brain cyst burdens compared with controls, both 2 weeks after treatment cessation and by 6 months p.i. Although a favourable effect on chronic infection may be specific for mice, these data merit investigation, since they may have clinical ramifications.en
dc.publisherElsevier, Amsterdam
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Antimicrobial Agents
dc.subjectToxoplasma gondiien
dc.subjectRH strainen
dc.subjectMe49 strainen
dc.subjectmurine modelsen
dc.subjectspiramycinen
dc.titleEffectiveness of spiramycin in murine models of acute and chronic toxoplasmosisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage230
dc.citation.issue3
dc.citation.other25(3): 226-230
dc.citation.rankM22
dc.citation.spage226
dc.citation.volume25
dc.identifier.doi10.1016/j.ijantimicag.2004.09.015
dc.identifier.pmid15737517
dc.identifier.scopus2-s2.0-14344259394
dc.identifier.wos000227997400008
dc.type.versionpublishedVersion


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