Influence of carvedilol on chronic renal failure progression in spontaneously hypertensive rats with adriamycin nephropathy
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Jovanović, DJovović, D.
Mihailović-Stanojević, Nevena

Miloradović, Zoran

Dimitrijević, J
Maksić, Nebojša
Đukanović, Ljubica

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Background: In this study, the effects of carvedilol, antihypertensive (alpha-beta blocker) agent with antiproliferative and antioxidative properties, on slowing down of chronic renal failure (CRF) progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy were examined. Methods: Eighty adult (24 weeks) SHR were divided into four groups: Control group: 20 SHR; ADR group: 20 SHR treated with ADR (2 mg/kg i.v. twice in 20 days); ADR-C group: 20 SHR treated with ADR and with carvedilol (30 mg/kg/day); ADR-CC group: 20 SHR treated with carvedilol and captopril (60 mg/kg/day). Systolic blood pressure was measured every two weeks, renal blood flow (RBF), mean arterial pressure (MAP) and renal vascular resistance (RVR) were determined at Weeks 6 and 12, creatinine clearance and proteinuria at Weeks -3 (see measurements), 6 and 12. The rats were sacrificed at Weeks 6 and 12 after the second ADR injection. Glomerular sclerosis, tubulointerstitial and blood vessel cha...nges were determined by semiquantitative scoring. Results: Carvedilol decreased systolic blood pressure. It decreased RVR and MAP, and increased RBF significantly. Carvedilol also significantly decreased interstitial infiltration in the early phase of the study, slowed down the development of interstitial fibrosis and tubular atrophy and decreased blood vessel changes. The hemodynamic and morphological effects of carvedilol were associated with slowing down the CRF progression as well as a mild decrease in proteinuria. Captopril addition to carvedilol improved its effects especially on prevention of tubulointerstitial changes. Conclusions: Results of this experimental study showed beneficial effect of carvedilol and its combination with captopril on CRF progression, indicating that clinical Studies are warranted.
Keywords:
adriamycin nephropathy / captopril / carvedilol / chronic renal failure progression / spontaneously hypertensive ratsSource:
Clinical Nephrology, 2005, 63, 6, 446-453Publisher:
- Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
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Institut za medicinska istraživanjaTY - JOUR AU - Jovanović, D AU - Jovović, D. AU - Mihailović-Stanojević, Nevena AU - Miloradović, Zoran AU - Dimitrijević, J AU - Maksić, Nebojša AU - Đukanović, Ljubica PY - 2005 UR - http://rimi.imi.bg.ac.rs/handle/123456789/109 AB - Background: In this study, the effects of carvedilol, antihypertensive (alpha-beta blocker) agent with antiproliferative and antioxidative properties, on slowing down of chronic renal failure (CRF) progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy were examined. Methods: Eighty adult (24 weeks) SHR were divided into four groups: Control group: 20 SHR; ADR group: 20 SHR treated with ADR (2 mg/kg i.v. twice in 20 days); ADR-C group: 20 SHR treated with ADR and with carvedilol (30 mg/kg/day); ADR-CC group: 20 SHR treated with carvedilol and captopril (60 mg/kg/day). Systolic blood pressure was measured every two weeks, renal blood flow (RBF), mean arterial pressure (MAP) and renal vascular resistance (RVR) were determined at Weeks 6 and 12, creatinine clearance and proteinuria at Weeks -3 (see measurements), 6 and 12. The rats were sacrificed at Weeks 6 and 12 after the second ADR injection. Glomerular sclerosis, tubulointerstitial and blood vessel changes were determined by semiquantitative scoring. Results: Carvedilol decreased systolic blood pressure. It decreased RVR and MAP, and increased RBF significantly. Carvedilol also significantly decreased interstitial infiltration in the early phase of the study, slowed down the development of interstitial fibrosis and tubular atrophy and decreased blood vessel changes. The hemodynamic and morphological effects of carvedilol were associated with slowing down the CRF progression as well as a mild decrease in proteinuria. Captopril addition to carvedilol improved its effects especially on prevention of tubulointerstitial changes. Conclusions: Results of this experimental study showed beneficial effect of carvedilol and its combination with captopril on CRF progression, indicating that clinical Studies are warranted. PB - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen T2 - Clinical Nephrology T1 - Influence of carvedilol on chronic renal failure progression in spontaneously hypertensive rats with adriamycin nephropathy EP - 453 IS - 6 SP - 446 VL - 63 UR - https://hdl.handle.net/21.15107/rcub_rimi_109 ER -
@article{ author = "Jovanović, D and Jovović, D. and Mihailović-Stanojević, Nevena and Miloradović, Zoran and Dimitrijević, J and Maksić, Nebojša and Đukanović, Ljubica", year = "2005", abstract = "Background: In this study, the effects of carvedilol, antihypertensive (alpha-beta blocker) agent with antiproliferative and antioxidative properties, on slowing down of chronic renal failure (CRF) progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy were examined. Methods: Eighty adult (24 weeks) SHR were divided into four groups: Control group: 20 SHR; ADR group: 20 SHR treated with ADR (2 mg/kg i.v. twice in 20 days); ADR-C group: 20 SHR treated with ADR and with carvedilol (30 mg/kg/day); ADR-CC group: 20 SHR treated with carvedilol and captopril (60 mg/kg/day). Systolic blood pressure was measured every two weeks, renal blood flow (RBF), mean arterial pressure (MAP) and renal vascular resistance (RVR) were determined at Weeks 6 and 12, creatinine clearance and proteinuria at Weeks -3 (see measurements), 6 and 12. The rats were sacrificed at Weeks 6 and 12 after the second ADR injection. Glomerular sclerosis, tubulointerstitial and blood vessel changes were determined by semiquantitative scoring. Results: Carvedilol decreased systolic blood pressure. It decreased RVR and MAP, and increased RBF significantly. Carvedilol also significantly decreased interstitial infiltration in the early phase of the study, slowed down the development of interstitial fibrosis and tubular atrophy and decreased blood vessel changes. The hemodynamic and morphological effects of carvedilol were associated with slowing down the CRF progression as well as a mild decrease in proteinuria. Captopril addition to carvedilol improved its effects especially on prevention of tubulointerstitial changes. Conclusions: Results of this experimental study showed beneficial effect of carvedilol and its combination with captopril on CRF progression, indicating that clinical Studies are warranted.", publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen", journal = "Clinical Nephrology", title = "Influence of carvedilol on chronic renal failure progression in spontaneously hypertensive rats with adriamycin nephropathy", pages = "453-446", number = "6", volume = "63", url = "https://hdl.handle.net/21.15107/rcub_rimi_109" }
Jovanović, D., Jovović, D., Mihailović-Stanojević, N., Miloradović, Z., Dimitrijević, J., Maksić, N.,& Đukanović, L.. (2005). Influence of carvedilol on chronic renal failure progression in spontaneously hypertensive rats with adriamycin nephropathy. in Clinical Nephrology Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 63(6), 446-453. https://hdl.handle.net/21.15107/rcub_rimi_109
Jovanović D, Jovović D, Mihailović-Stanojević N, Miloradović Z, Dimitrijević J, Maksić N, Đukanović L. Influence of carvedilol on chronic renal failure progression in spontaneously hypertensive rats with adriamycin nephropathy. in Clinical Nephrology. 2005;63(6):446-453. https://hdl.handle.net/21.15107/rcub_rimi_109 .
Jovanović, D, Jovović, D., Mihailović-Stanojević, Nevena, Miloradović, Zoran, Dimitrijević, J, Maksić, Nebojša, Đukanović, Ljubica, "Influence of carvedilol on chronic renal failure progression in spontaneously hypertensive rats with adriamycin nephropathy" in Clinical Nephrology, 63, no. 6 (2005):446-453, https://hdl.handle.net/21.15107/rcub_rimi_109 .