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Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

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2021
1084.pdf (1.001Mb)
Authors
Vulić, Katarina
Bjekić, Jovana
Paunović, Dunja
Jovanović, Miloš
Milanović, Slađan
Filipović, Saša
Article (Published version)
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Abstract
Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences be...tween oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.

Source:
Scientific Reports, 2021, 11, 1, 3013-
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.1038/s41598-021-82577-7

ISSN: 2045-2322

PubMed: 33542344

WoS: 000618048600012

Scopus: 2-s2.0-85100511002
[ Google Scholar ]
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4
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1087
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Vulić, Katarina
AU  - Bjekić, Jovana
AU  - Paunović, Dunja
AU  - Jovanović, Miloš
AU  - Milanović, Slađan
AU  - Filipović, Saša
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1087
AB  - Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.
T2  - Scientific Reports
T1  - Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
IS  - 1
SP  - 3013
VL  - 11
DO  - 10.1038/s41598-021-82577-7
UR  - conv_5058
ER  - 
@article{
author = "Vulić, Katarina and Bjekić, Jovana and Paunović, Dunja and Jovanović, Miloš and Milanović, Slađan and Filipović, Saša",
year = "2021",
abstract = "Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.",
journal = "Scientific Reports",
title = "Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory",
number = "1",
pages = "3013",
volume = "11",
doi = "10.1038/s41598-021-82577-7",
url = "conv_5058"
}
Vulić, K., Bjekić, J., Paunović, D., Jovanović, M., Milanović, S.,& Filipović, S.. (2021). Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory. in Scientific Reports, 11(1), 3013.
https://doi.org/10.1038/s41598-021-82577-7
conv_5058
Vulić K, Bjekić J, Paunović D, Jovanović M, Milanović S, Filipović S. Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory. in Scientific Reports. 2021;11(1):3013.
doi:10.1038/s41598-021-82577-7
conv_5058 .
Vulić, Katarina, Bjekić, Jovana, Paunović, Dunja, Jovanović, Miloš, Milanović, Slađan, Filipović, Saša, "Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory" in Scientific Reports, 11, no. 1 (2021):3013,
https://doi.org/10.1038/s41598-021-82577-7 .,
conv_5058 .

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