Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

2021
Authors
Vulić, Katarina
Bjekić, Jovana

Paunović, Dunja

Jovanović, Miloš
Milanović, Slađan

Filipović, Saša

Article (Published version)
Metadata
Show full item recordAbstract
Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences be...tween oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.
Source:
Scientific Reports, 2021, 11, 1, 3013-Funding / projects:
DOI: 10.1038/s41598-021-82577-7
ISSN: 2045-2322
PubMed: 33542344
WoS: 000618048600012
Scopus: 2-s2.0-85100511002
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Vulić, Katarina AU - Bjekić, Jovana AU - Paunović, Dunja AU - Jovanović, Miloš AU - Milanović, Slađan AU - Filipović, Saša PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1087 AB - Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further. T2 - Scientific Reports T1 - Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory IS - 1 SP - 3013 VL - 11 DO - 10.1038/s41598-021-82577-7 UR - conv_5058 ER -
@article{ author = "Vulić, Katarina and Bjekić, Jovana and Paunović, Dunja and Jovanović, Miloš and Milanović, Slađan and Filipović, Saša", year = "2021", abstract = "Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.", journal = "Scientific Reports", title = "Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory", number = "1", pages = "3013", volume = "11", doi = "10.1038/s41598-021-82577-7", url = "conv_5058" }
Vulić, K., Bjekić, J., Paunović, D., Jovanović, M., Milanović, S.,& Filipović, S.. (2021). Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory. in Scientific Reports, 11(1), 3013. https://doi.org/10.1038/s41598-021-82577-7 conv_5058
Vulić K, Bjekić J, Paunović D, Jovanović M, Milanović S, Filipović S. Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory. in Scientific Reports. 2021;11(1):3013. doi:10.1038/s41598-021-82577-7 conv_5058 .
Vulić, Katarina, Bjekić, Jovana, Paunović, Dunja, Jovanović, Miloš, Milanović, Slađan, Filipović, Saša, "Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory" in Scientific Reports, 11, no. 1 (2021):3013, https://doi.org/10.1038/s41598-021-82577-7 ., conv_5058 .