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dc.creatorMaslovarić, Irina
dc.creatorIlić, Vesna
dc.creatorDrvenica, Ivana
dc.creatorStančić, Ana
dc.creatorMojsilović, Slavko
dc.creatorKukolj, Tamara
dc.creatorBugarski, Diana
dc.creatorSaso, Luciano
dc.creatorNicoletti, Marcello
dc.date.accessioned2021-04-20T13:12:04Z
dc.date.available2021-04-20T13:12:04Z
dc.date.issued2021
dc.identifier.issn2223-7747
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1086
dc.description.abstractHenna is the current name of the dye prepared from the dry leaf powder of Lawsonia inermis (Lythraceae). Several studies have focused on the chemistry and pharmacology of the henna dyeing active compound, lawsone, obtained from the main constituents of leaves, hennosides, during the processing of plant material. However, knowledge regarding the biological activity of hennosides is largely lacking. In this paper, the redox activity of three hennoside isomers is reported. The pro-oxidative activity was confirmed by their ability to induce mild lysis of erythrocytes and to increase the level of methemoglobin at the concentration gt = 500 mu g/mL. The antioxidant activity of hennosides (concentration gt = 100 mu g/mL) was determined by FRAP and ABTS assays. At concentration of 500 mu g/mL, antioxidant activity of hennoside isomers was equivalent to 0.46 +/- 0.08, 0.62 +/- 0.28 and 0.35 +/- 0.03 mM FeSO4 x 7H(2)O, and 0.15 +/- 0.01, 0.30 +/- 0.01 and 0.09 +/- 0.01 mM Trolox. Hennosides at 100 mu g/mL concentration did not influence viability of human breast cancer cell lines MDA231 and MCF-7 and primary human peripheral blood and periodontal ligament-mesenchymal stem cells, but produced a modest increase in concentration of antioxidants in the cell culture supernatants. The evidenced antioxidant and pro-oxidant activities indicate their potential to act as redox balance regulator, which opens up the possibility of using hennosides in commercial phytomedicines.en
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePlants-Basel
dc.subjectLawsonia inermisen
dc.subjectLythraceaeen
dc.subjectglucosidesen
dc.subjectredox activityen
dc.titleInsight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Insteaden
dc.typearticle
dc.rights.licenseBY
dc.citation.issue2
dc.citation.other10(2): -
dc.citation.spage237
dc.citation.volume10
dc.identifier.doi10.3390/plants10020237
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/69/1083.pdf
dc.identifier.pmid33530539
dc.identifier.scopus2-s2.0-85099965242
dc.identifier.wos000623002400001
dc.type.versionpublishedVersion


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