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Insight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Instead

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2021
1083.pdf (1.383Mb)
Authors
Maslovarić, Irina
Ilić, Vesna
Drvenica, Ivana
Stančić, Ana
Mojsilović, Slavko
Kukolj, Tamara
Bugarski, Diana
Saso, Luciano
Nicoletti, Marcello
Article (Published version)
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Abstract
Henna is the current name of the dye prepared from the dry leaf powder of Lawsonia inermis (Lythraceae). Several studies have focused on the chemistry and pharmacology of the henna dyeing active compound, lawsone, obtained from the main constituents of leaves, hennosides, during the processing of plant material. However, knowledge regarding the biological activity of hennosides is largely lacking. In this paper, the redox activity of three hennoside isomers is reported. The pro-oxidative activity was confirmed by their ability to induce mild lysis of erythrocytes and to increase the level of methemoglobin at the concentration gt = 500 mu g/mL. The antioxidant activity of hennosides (concentration gt = 100 mu g/mL) was determined by FRAP and ABTS assays. At concentration of 500 mu g/mL, antioxidant activity of hennoside isomers was equivalent to 0.46 +/- 0.08, 0.62 +/- 0.28 and 0.35 +/- 0.03 mM FeSO4 x 7H(2)O, and 0.15 +/- 0.01, 0.30 +/- 0.01 and 0.09 +/- 0.01 mM Trolox. Hennosides at... 100 mu g/mL concentration did not influence viability of human breast cancer cell lines MDA231 and MCF-7 and primary human peripheral blood and periodontal ligament-mesenchymal stem cells, but produced a modest increase in concentration of antioxidants in the cell culture supernatants. The evidenced antioxidant and pro-oxidant activities indicate their potential to act as redox balance regulator, which opens up the possibility of using hennosides in commercial phytomedicines.

Keywords:
Lawsonia inermis / Lythraceae / glucosides / redox activity
Source:
Plants-Basel, 2021, 10, 2, 237-
Publisher:
  • MDPI
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.3390/plants10020237

ISSN: 2223-7747

PubMed: 33530539

WoS: 000623002400001

Scopus: 2-s2.0-85099965242
[ Google Scholar ]
2
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1086
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Maslovarić, Irina
AU  - Ilić, Vesna
AU  - Drvenica, Ivana
AU  - Stančić, Ana
AU  - Mojsilović, Slavko
AU  - Kukolj, Tamara
AU  - Bugarski, Diana
AU  - Saso, Luciano
AU  - Nicoletti, Marcello
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1086
AB  - Henna is the current name of the dye prepared from the dry leaf powder of Lawsonia inermis (Lythraceae). Several studies have focused on the chemistry and pharmacology of the henna dyeing active compound, lawsone, obtained from the main constituents of leaves, hennosides, during the processing of plant material. However, knowledge regarding the biological activity of hennosides is largely lacking. In this paper, the redox activity of three hennoside isomers is reported. The pro-oxidative activity was confirmed by their ability to induce mild lysis of erythrocytes and to increase the level of methemoglobin at the concentration  gt = 500 mu g/mL. The antioxidant activity of hennosides (concentration  gt = 100 mu g/mL) was determined by FRAP and ABTS assays. At concentration of 500 mu g/mL, antioxidant activity of hennoside isomers was equivalent to 0.46 +/- 0.08, 0.62 +/- 0.28 and 0.35 +/- 0.03 mM FeSO4 x 7H(2)O, and 0.15 +/- 0.01, 0.30 +/- 0.01 and 0.09 +/- 0.01 mM Trolox. Hennosides at 100 mu g/mL concentration did not influence viability of human breast cancer cell lines MDA231 and MCF-7 and primary human peripheral blood and periodontal ligament-mesenchymal stem cells, but produced a modest increase in concentration of antioxidants in the cell culture supernatants. The evidenced antioxidant and pro-oxidant activities indicate their potential to act as redox balance regulator, which opens up the possibility of using hennosides in commercial phytomedicines.
PB  - MDPI
T2  - Plants-Basel
T1  - Insight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Instead
IS  - 2
SP  - 237
VL  - 10
DO  - 10.3390/plants10020237
ER  - 
@article{
author = "Maslovarić, Irina and Ilić, Vesna and Drvenica, Ivana and Stančić, Ana and Mojsilović, Slavko and Kukolj, Tamara and Bugarski, Diana and Saso, Luciano and Nicoletti, Marcello",
year = "2021",
abstract = "Henna is the current name of the dye prepared from the dry leaf powder of Lawsonia inermis (Lythraceae). Several studies have focused on the chemistry and pharmacology of the henna dyeing active compound, lawsone, obtained from the main constituents of leaves, hennosides, during the processing of plant material. However, knowledge regarding the biological activity of hennosides is largely lacking. In this paper, the redox activity of three hennoside isomers is reported. The pro-oxidative activity was confirmed by their ability to induce mild lysis of erythrocytes and to increase the level of methemoglobin at the concentration  gt = 500 mu g/mL. The antioxidant activity of hennosides (concentration  gt = 100 mu g/mL) was determined by FRAP and ABTS assays. At concentration of 500 mu g/mL, antioxidant activity of hennoside isomers was equivalent to 0.46 +/- 0.08, 0.62 +/- 0.28 and 0.35 +/- 0.03 mM FeSO4 x 7H(2)O, and 0.15 +/- 0.01, 0.30 +/- 0.01 and 0.09 +/- 0.01 mM Trolox. Hennosides at 100 mu g/mL concentration did not influence viability of human breast cancer cell lines MDA231 and MCF-7 and primary human peripheral blood and periodontal ligament-mesenchymal stem cells, but produced a modest increase in concentration of antioxidants in the cell culture supernatants. The evidenced antioxidant and pro-oxidant activities indicate their potential to act as redox balance regulator, which opens up the possibility of using hennosides in commercial phytomedicines.",
publisher = "MDPI",
journal = "Plants-Basel",
title = "Insight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Instead",
number = "2",
pages = "237",
volume = "10",
doi = "10.3390/plants10020237"
}
Maslovarić, I., Ilić, V., Drvenica, I., Stančić, A., Mojsilović, S., Kukolj, T., Bugarski, D., Saso, L.,& Nicoletti, M.. (2021). Insight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Instead. in Plants-Basel
MDPI., 10(2), 237.
https://doi.org/10.3390/plants10020237
conv_4980
Maslovarić I, Ilić V, Drvenica I, Stančić A, Mojsilović S, Kukolj T, Bugarski D, Saso L, Nicoletti M. Insight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Instead. in Plants-Basel. 2021;10(2):237.
doi:10.3390/plants10020237
conv_4980 .
Maslovarić, Irina, Ilić, Vesna, Drvenica, Ivana, Stančić, Ana, Mojsilović, Slavko, Kukolj, Tamara, Bugarski, Diana, Saso, Luciano, Nicoletti, Marcello, "Insight into the Biological Activity of Hennosides-Glucosides Isolated from Lawsonia inermis (henna): Could They Be Regarded as Active Constituents Instead" in Plants-Basel, 10, no. 2 (2021):237,
https://doi.org/10.3390/plants10020237 .,
conv_4980 .

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