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Impact of depression on gait variability in Parkinson's disease

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2021
1073.pdf (879.8Kb)
Authors
Dragašević-Mišković, Nataša
Bobić, Vladislava
Kostić, Milutin
Stanković, Iva
Radovanović, Saša M.
Dimitrijević, Kosta
Svetel, Marina
Petrović, Igor
Đurić-Jovičić, Milica
Article (Published version)
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Abstract
Objective The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed. Patients and Methods Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods. Results Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variabilit...y was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients. Conclusions Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task. Significance Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.

Keywords:
Parkinson's disease / Depression / Gait analysis / Gait variability / Dual-task paradigm
Source:
Clinical Neurology & Neurosurgery, 2021, 200, 106324-
Publisher:
  • Elsevier, Amsterdam
Funding / projects:
  • Motor and non-motor symptoms and signs in parkinsonism: clinical, morphological and molecular-genetic correlates (RS-175090)
  • Effects of assistive systems in neurorehabilitation: recovery of sensory-motor functions (RS-175016)

DOI: 10.1016/j.clineuro.2020.106324

ISSN: 0303-8467

PubMed: 33129594

WoS: 000608127700018

Scopus: 2-s2.0-85094571885
[ Google Scholar ]
8
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1076
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Dragašević-Mišković, Nataša
AU  - Bobić, Vladislava
AU  - Kostić, Milutin
AU  - Stanković, Iva
AU  - Radovanović, Saša M.
AU  - Dimitrijević, Kosta
AU  - Svetel, Marina
AU  - Petrović, Igor
AU  - Đurić-Jovičić, Milica
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1076
AB  - Objective

The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Patients and Methods

Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Results

Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Conclusions

Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Significance

Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.
PB  - Elsevier, Amsterdam
T2  - Clinical Neurology & Neurosurgery
T1  - Impact of depression on gait variability in Parkinson's disease
SP  - 106324
VL  - 200
DO  - 10.1016/j.clineuro.2020.106324
UR  - conv_4960
ER  - 
@article{
author = "Dragašević-Mišković, Nataša and Bobić, Vladislava and Kostić, Milutin and Stanković, Iva and Radovanović, Saša M. and Dimitrijević, Kosta and Svetel, Marina and Petrović, Igor and Đurić-Jovičić, Milica",
year = "2021",
abstract = "Objective

The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Patients and Methods

Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Results

Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Conclusions

Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Significance

Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.",
publisher = "Elsevier, Amsterdam",
journal = "Clinical Neurology & Neurosurgery",
title = "Impact of depression on gait variability in Parkinson's disease",
pages = "106324",
volume = "200",
doi = "10.1016/j.clineuro.2020.106324",
url = "conv_4960"
}
Dragašević-Mišković, N., Bobić, V., Kostić, M., Stanković, I., Radovanović, S. M., Dimitrijević, K., Svetel, M., Petrović, I.,& Đurić-Jovičić, M.. (2021). Impact of depression on gait variability in Parkinson's disease. in Clinical Neurology & Neurosurgery
Elsevier, Amsterdam., 200, 106324.
https://doi.org/10.1016/j.clineuro.2020.106324
conv_4960
Dragašević-Mišković N, Bobić V, Kostić M, Stanković I, Radovanović SM, Dimitrijević K, Svetel M, Petrović I, Đurić-Jovičić M. Impact of depression on gait variability in Parkinson's disease. in Clinical Neurology & Neurosurgery. 2021;200:106324.
doi:10.1016/j.clineuro.2020.106324
conv_4960 .
Dragašević-Mišković, Nataša, Bobić, Vladislava, Kostić, Milutin, Stanković, Iva, Radovanović, Saša M., Dimitrijević, Kosta, Svetel, Marina, Petrović, Igor, Đurić-Jovičić, Milica, "Impact of depression on gait variability in Parkinson's disease" in Clinical Neurology & Neurosurgery, 200 (2021):106324,
https://doi.org/10.1016/j.clineuro.2020.106324 .,
conv_4960 .

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