Impact of depression on gait variability in Parkinson's disease

2021
Authors
Dragašević-Mišković, NatašaBobić, Vladislava

Kostić, Milutin
Stanković, Iva
Radovanović, Saša M.

Dimitrijević, Kosta
Svetel, Marina
Petrović, Igor
Đurić-Jovičić, Milica
Article (Published version)

Metadata
Show full item recordAbstract
Objective
The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Patients and Methods
Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Results
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variabilit...y was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Conclusions
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Significance
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.
Keywords:
Parkinson's disease / Depression / Gait analysis / Gait variability / Dual-task paradigmSource:
Clinical Neurology & Neurosurgery, 2021, 200, 106324-Publisher:
- Elsevier, Amsterdam
Funding / projects:
- Motor and non-motor symptoms and signs in parkinsonism: clinical, morphological and molecular-genetic correlates (RS-175090)
- Effects of assistive systems in neurorehabilitation: recovery of sensory-motor functions (RS-175016)
DOI: 10.1016/j.clineuro.2020.106324
ISSN: 0303-8467
PubMed: 33129594
WoS: 000608127700018
Scopus: 2-s2.0-85094571885
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Dragašević-Mišković, Nataša AU - Bobić, Vladislava AU - Kostić, Milutin AU - Stanković, Iva AU - Radovanović, Saša M. AU - Dimitrijević, Kosta AU - Svetel, Marina AU - Petrović, Igor AU - Đurić-Jovičić, Milica PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1076 AB - Objective The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed. Patients and Methods Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods. Results Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients. Conclusions Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task. Significance Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients. PB - Elsevier, Amsterdam T2 - Clinical Neurology & Neurosurgery T1 - Impact of depression on gait variability in Parkinson's disease SP - 106324 VL - 200 DO - 10.1016/j.clineuro.2020.106324 ER -
@article{ author = "Dragašević-Mišković, Nataša and Bobić, Vladislava and Kostić, Milutin and Stanković, Iva and Radovanović, Saša M. and Dimitrijević, Kosta and Svetel, Marina and Petrović, Igor and Đurić-Jovičić, Milica", year = "2021", abstract = "Objective The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed. Patients and Methods Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods. Results Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients. Conclusions Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task. Significance Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.", publisher = "Elsevier, Amsterdam", journal = "Clinical Neurology & Neurosurgery", title = "Impact of depression on gait variability in Parkinson's disease", pages = "106324", volume = "200", doi = "10.1016/j.clineuro.2020.106324" }
Dragašević-Mišković, N., Bobić, V., Kostić, M., Stanković, I., Radovanović, S. M., Dimitrijević, K., Svetel, M., Petrović, I.,& Đurić-Jovičić, M.. (2021). Impact of depression on gait variability in Parkinson's disease. in Clinical Neurology & Neurosurgery Elsevier, Amsterdam., 200, 106324. https://doi.org/10.1016/j.clineuro.2020.106324
Dragašević-Mišković N, Bobić V, Kostić M, Stanković I, Radovanović SM, Dimitrijević K, Svetel M, Petrović I, Đurić-Jovičić M. Impact of depression on gait variability in Parkinson's disease. in Clinical Neurology & Neurosurgery. 2021;200:106324. doi:10.1016/j.clineuro.2020.106324 .
Dragašević-Mišković, Nataša, Bobić, Vladislava, Kostić, Milutin, Stanković, Iva, Radovanović, Saša M., Dimitrijević, Kosta, Svetel, Marina, Petrović, Igor, Đurić-Jovičić, Milica, "Impact of depression on gait variability in Parkinson's disease" in Clinical Neurology & Neurosurgery, 200 (2021):106324, https://doi.org/10.1016/j.clineuro.2020.106324 . .