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Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?

Samo za registrovane korisnike
2021
Autori
Arsić, Aleksandra
Takić, Marija M.
Kojadinović, Milica
Petrović, Snježana B.
Paunović, Marija P.
Vučić, Vesna M.
Ristić-Medić, Danijela K.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a ...higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.

Ključne reči:
obesity / cardiometabolic markers / metabolically healthy obesity / dietary PUFA intake / PUFA status / eicosapentaenoic acid / docosahexaenoic acid / desaturases / elongase
Izvor:
Canadian Journal of Physiology & Pharmacology, 2021, 99, 1, 64-71
Izdavač:
  • Canadian Science Publishing, Ottawa
Finansiranje / projekti:
  • Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 200015 (Univerzitet u Beogradu, Institut za medicinska istraživanja) (RS-200015)

DOI: 10.1139/cjpp-2020-0317

ISSN: 0008-4212

PubMed: 32822561

WoS: 000613249900009

Scopus: 2-s2.0-85099803906
[ Google Scholar ]
5
1
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1070
Kolekcije
  • Radovi istraživača / Researchers' publications
Institucija/grupa
Institut za medicinska istraživanja
TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Takić, Marija M.
AU  - Kojadinović, Milica
AU  - Petrović, Snježana B.
AU  - Paunović, Marija P.
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela K.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1070
AB  - The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?
EP  - 71
IS  - 1
SP  - 64
VL  - 99
DO  - 10.1139/cjpp-2020-0317
ER  - 
@article{
author = "Arsić, Aleksandra and Takić, Marija M. and Kojadinović, Milica and Petrović, Snježana B. and Paunović, Marija P. and Vučić, Vesna M. and Ristić-Medić, Danijela K.",
year = "2021",
abstract = "The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?",
pages = "71-64",
number = "1",
volume = "99",
doi = "10.1139/cjpp-2020-0317"
}
Arsić, A., Takić, M. M., Kojadinović, M., Petrović, S. B., Paunović, M. P., Vučić, V. M.,& Ristić-Medić, D. K.. (2021). Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 99(1), 64-71.
https://doi.org/10.1139/cjpp-2020-0317
Arsić A, Takić MM, Kojadinović M, Petrović SB, Paunović MP, Vučić VM, Ristić-Medić DK. Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology. 2021;99(1):64-71.
doi:10.1139/cjpp-2020-0317 .
Arsić, Aleksandra, Takić, Marija M., Kojadinović, Milica, Petrović, Snježana B., Paunović, Marija P., Vučić, Vesna M., Ristić-Medić, Danijela K., "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?" in Canadian Journal of Physiology & Pharmacology, 99, no. 1 (2021):64-71,
https://doi.org/10.1139/cjpp-2020-0317 . .

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