RIMI - Repository of the Institute for Medical Research
Institute for Medical Research
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   RIMI
  • Institut za medicinska istraživanja
  • Radovi istraživača / Researchers' publications
  • View Item
  •   RIMI
  • Institut za medicinska istraživanja
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?

Authorized Users Only
2021
Authors
Arsić, Aleksandra
Takić, Marija M.
Kojadinović, Milica
Petrović, Snježana B.
Paunović, Marija P.
Vučić, Vesna M.
Ristić-Medić, Danijela K.
Article (Published version)
Metadata
Show full item record
Abstract
The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a ...higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.

Keywords:
obesity / cardiometabolic markers / metabolically healthy obesity / dietary PUFA intake / PUFA status / eicosapentaenoic acid / docosahexaenoic acid / desaturases / elongase
Source:
Canadian Journal of Physiology & Pharmacology, 2021, 99, 1, 64-71
Publisher:
  • Canadian Science Publishing, Ottawa
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.1139/cjpp-2020-0317

ISSN: 0008-4212

PubMed: 32822561

WoS: 000613249900009

Scopus: 2-s2.0-85099803906
[ Google Scholar ]
4
1
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1070
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Takić, Marija M.
AU  - Kojadinović, Milica
AU  - Petrović, Snježana B.
AU  - Paunović, Marija P.
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela K.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1070
AB  - The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?
EP  - 71
IS  - 1
SP  - 64
VL  - 99
DO  - 10.1139/cjpp-2020-0317
UR  - conv_4968
ER  - 
@article{
author = "Arsić, Aleksandra and Takić, Marija M. and Kojadinović, Milica and Petrović, Snježana B. and Paunović, Marija P. and Vučić, Vesna M. and Ristić-Medić, Danijela K.",
year = "2021",
abstract = "The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?",
pages = "71-64",
number = "1",
volume = "99",
doi = "10.1139/cjpp-2020-0317",
url = "conv_4968"
}
Arsić, A., Takić, M. M., Kojadinović, M., Petrović, S. B., Paunović, M. P., Vučić, V. M.,& Ristić-Medić, D. K.. (2021). Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 99(1), 64-71.
https://doi.org/10.1139/cjpp-2020-0317
conv_4968
Arsić A, Takić MM, Kojadinović M, Petrović SB, Paunović MP, Vučić VM, Ristić-Medić DK. Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology. 2021;99(1):64-71.
doi:10.1139/cjpp-2020-0317
conv_4968 .
Arsić, Aleksandra, Takić, Marija M., Kojadinović, Milica, Petrović, Snježana B., Paunović, Marija P., Vučić, Vesna M., Ristić-Medić, Danijela K., "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?" in Canadian Journal of Physiology & Pharmacology, 99, no. 1 (2021):64-71,
https://doi.org/10.1139/cjpp-2020-0317 .,
conv_4968 .

DSpace software copyright © 2002-2015  DuraSpace
About RIMI | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About RIMI | Send Feedback

OpenAIRERCUB