Приказ основних података о документу

dc.creatorHerrmann, Marietta
dc.creatorDiederichs, S.
dc.creatorMelnik, S.
dc.creatorRiegger, J.
dc.creatorTrivanović, Drenka
dc.creatorLi, S.
dc.creatorJenei-Lanzl, Z.
dc.creatorBrenner, R.E.
dc.creatorHuber-Lang, M.
dc.creatorZaucke, F.
dc.creatorSchildberg, F.A.
dc.creatorGrässel, S.
dc.date.accessioned2021-04-20T13:10:57Z
dc.date.available2021-04-20T13:10:57Z
dc.date.issued2021
dc.identifier.issn2296-4185
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1069
dc.description.abstractThe incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pathologies as well as suggested as treatment option. EVs play a pivotal role in communication between cells and their environment. Thereby, the EV cargo is highly dependent on their cellular origin. In this review, we summarize putative mechanisms by which EVs can contribute to musculoskeletal tissue homeostasis, regeneration and disease, in particular matrix remodeling and mineralization, pro-angiogenic effects and immunomodulatory activities. Mesenchymal stromal cells (MSCs) present the most frequently used cell source for EV generation for musculoskeletal applications, and herein we discuss how the MSC phenotype can influence the cargo and thus the regenerative potential of EVs. Induced pluripotent stem cell-derived mesenchymal progenitor cells (iMPs) may overcome current limitations of MSCs, and iMP-derived EVs are discussed as an alternative strategy. In the last part of the article, we focus on therapeutic applications of EVs and discuss both practical considerations for EV production and the current state of EV-based therapies.en
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Bioengineering & Biotechnology
dc.subjectcell-free therapeuticsen
dc.subjectexosomesen
dc.subjectextracellular vesiclesen
dc.subjectiMPen
dc.subjectMSCen
dc.subjectmusculoskeletal diseasesen
dc.titleExtracellular Vesicles in Musculoskeletal Pathologies and Regenerationen
dc.typearticle
dc.rights.licenseBY
dc.citation.other8: -
dc.citation.rankM21~
dc.citation.volume8
dc.identifier.doi10.3389/fbioe.2020.624096
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/55/1066.pdf
dc.identifier.scopus2-s2.0-85100542773
dc.type.versionpublishedVersion


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