Приказ основних података о документу

dc.creatorJauković, Aleksandra
dc.creatorAbadjieva, Desislava
dc.creatorTrivanović, Drenka
dc.creatorStoyanova, Elena
dc.creatorKostadinova, Milena
dc.creatorPashova, Shina
dc.creatorKestendjieva, Snejana
dc.creatorKukolj, Tamara
dc.creatorJešeta, Michal
dc.creatorKistanova, Elena
dc.creatorMourdjeva, Milena
dc.date.accessioned2021-04-20T13:10:03Z
dc.date.available2021-04-20T13:10:03Z
dc.date.issued2020
dc.identifier.issn2629-3269
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1055
dc.description.abstractMesenchymal stem cells (MSC) have been considered the promising candidates for the regenerative and personalized medicine due to their self-renewal potential, multilineage differentiation and immunomodulatory capacity. Although these properties have encouraged profound MSC studies in recent years, the majority of research has been based on standard 2D culture utilization. The opportunity to resemble in vivo characteristics of cells native niche has been provided by implementation of 3D culturing models such as MSC spheroid formation assesed through cells self-assembling. In this review, we address the current literature on physical and biochemical features of 3D MSC spheroid microenvironment and their impact on MSC properties and behaviors. Starting with the reduction in the cells' dimensions and volume due to the changes in adhesion molecules expression and cytoskeletal proteins rearrangement resembling native conditions, through the microenvironment shifts in oxygen, nutrients and metabolites gradients and demands, we focus on distinctive and beneficial features of MSC in spheroids compared to cells cultured in 2D conditions. By summarizing the data for 3D MSC spheroids regarding cell survival, pluripotency, differentiation, immunomodulatory activities and potential to affect tumor cells growth we highlighted advantages and perspectives of MSC spheroids use in regenerative medicine. Further detailed analyses are needed to deepen our understanding of mechanisms responsible for modified MSC behavior in spheroids and to set future directions for MSC clinical application.en
dc.publisherSpringer, New York
dc.relationCOST action [CA16119 - Action CellFit]
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS//
dc.relationBulgarian National Science Fund, Sofia, Bulgaria [DCOST01/18, KP-06COST/21]
dc.relationMinistry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LTC-18059]
dc.rightsrestrictedAccess
dc.sourceStem Cell Reviews & Reports
dc.subjectMesenchymal stem cellsen
dc.subject3D spheroids microenvironmenten
dc.subjectMorphological changesen
dc.subjectCell survivalen
dc.subjectEnergy metabolismen
dc.subjectEpigenetic regulationen
dc.subjectImproved functionalityen
dc.titleSpecificity of 3D MSC Spheroids Microenvironment: Impact on MSC Behavior and Propertiesen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage875
dc.citation.issue5
dc.citation.other16(5): 853-875
dc.citation.rankM21~
dc.citation.spage853
dc.citation.volume16
dc.identifier.doi10.1007/s12015-020-10006-9
dc.identifier.pmid32681232
dc.identifier.scopus2-s2.0-85088108884
dc.identifier.wos000549663600001
dc.type.versionpublishedVersion


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Приказ основних података о документу