Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study

2020
Аутори
Resanović, Ivana
Gluvić, Zoran

Zarić, Božidarka

Sudar-Milovanović, Emina

Vučić, Vesna M.

Arsić, Aleksandra

Nedić, Olgica

Sunderić, Miloš

Gligorijević, Nikola

Milačić, Davorka
Isenović, Esma R.
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of... total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.
Кључне речи:
fatty acids / hyperbaric oxygen / insulin-like growth factor binding protein 1 / type 1 diabetes mellitus / lipids / vascular complicationsИзвор:
Canadian Journal of Diabetes, 2020, 44, 1, 22-29Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-173033)
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-41030)
- Структурне карактеристике везујућих протеина и рецептора за инсулину сличне факторе раста (IGF), њихове интеракције са другим физиолошким молекулима и промене код поремећаја метаболизма (RS-173042)
DOI: 10.1016/j.jcjd.2019.04.018
ISSN: 1499-2671
PubMed: 31311728
WoS: 000512334700006
Scopus: 2-s2.0-85068858273
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Resanović, Ivana AU - Gluvić, Zoran AU - Zarić, Božidarka AU - Sudar-Milovanović, Emina AU - Vučić, Vesna M. AU - Arsić, Aleksandra AU - Nedić, Olgica AU - Sunderić, Miloš AU - Gligorijević, Nikola AU - Milačić, Davorka AU - Isenović, Esma R. PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1042 AB - Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition. PB - Elsevier, Amsterdam T2 - Canadian Journal of Diabetes T1 - Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study EP - 29 IS - 1 SP - 22 VL - 44 DO - 10.1016/j.jcjd.2019.04.018 ER -
@article{ author = "Resanović, Ivana and Gluvić, Zoran and Zarić, Božidarka and Sudar-Milovanović, Emina and Vučić, Vesna M. and Arsić, Aleksandra and Nedić, Olgica and Sunderić, Miloš and Gligorijević, Nikola and Milačić, Davorka and Isenović, Esma R.", year = "2020", abstract = "Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.", publisher = "Elsevier, Amsterdam", journal = "Canadian Journal of Diabetes", title = "Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study", pages = "29-22", number = "1", volume = "44", doi = "10.1016/j.jcjd.2019.04.018" }
Resanović, I., Gluvić, Z., Zarić, B., Sudar-Milovanović, E., Vučić, V. M., Arsić, A., Nedić, O., Sunderić, M., Gligorijević, N., Milačić, D.,& Isenović, E. R.. (2020). Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study. in Canadian Journal of Diabetes Elsevier, Amsterdam., 44(1), 22-29. https://doi.org/10.1016/j.jcjd.2019.04.018
Resanović I, Gluvić Z, Zarić B, Sudar-Milovanović E, Vučić VM, Arsić A, Nedić O, Sunderić M, Gligorijević N, Milačić D, Isenović ER. Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study. in Canadian Journal of Diabetes. 2020;44(1):22-29. doi:10.1016/j.jcjd.2019.04.018 .
Resanović, Ivana, Gluvić, Zoran, Zarić, Božidarka, Sudar-Milovanović, Emina, Vučić, Vesna M., Arsić, Aleksandra, Nedić, Olgica, Sunderić, Miloš, Gligorijević, Nikola, Milačić, Davorka, Isenović, Esma R., "Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study" in Canadian Journal of Diabetes, 44, no. 1 (2020):22-29, https://doi.org/10.1016/j.jcjd.2019.04.018 . .