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Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study
Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of... total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.
TY - JOUR
AU - Resanović, Ivana
AU - Gluvić, Zoran
AU - Zarić, Božidarka
AU - Sudar-Milovanović, Emina
AU - Vučić, Vesna M.
AU - Arsić, Aleksandra
AU - Nedić, Olgica
AU - Sunderić, Miloš
AU - Gligorijević, Nikola
AU - Milačić, Davorka
AU - Isenović, Esma R.
PY - 2020
UR - http://rimi.imi.bg.ac.rs/handle/123456789/1042
AB - Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.
PB - Elsevier, Amsterdam
T2 - Canadian Journal of Diabetes
T1 - Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study
EP - 29
IS - 1
SP - 22
VL - 44
DO - 10.1016/j.jcjd.2019.04.018
ER -
@article{
author = "Resanović, Ivana and Gluvić, Zoran and Zarić, Božidarka and Sudar-Milovanović, Emina and Vučić, Vesna M. and Arsić, Aleksandra and Nedić, Olgica and Sunderić, Miloš and Gligorijević, Nikola and Milačić, Davorka and Isenović, Esma R.",
year = "2020",
abstract = "Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.",
publisher = "Elsevier, Amsterdam",
journal = "Canadian Journal of Diabetes",
title = "Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study",
pages = "29-22",
number = "1",
volume = "44",
doi = "10.1016/j.jcjd.2019.04.018"
}
Resanović, I., Gluvić, Z., Zarić, B., Sudar-Milovanović, E., Vučić, V. M., Arsić, A., Nedić, O., Sunderić, M., Gligorijević, N., Milačić, D.,& Isenović, E. R.. (2020). Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study. in Canadian Journal of Diabetes
Elsevier, Amsterdam., 44(1), 22-29.
https://doi.org/10.1016/j.jcjd.2019.04.018
Resanović I, Gluvić Z, Zarić B, Sudar-Milovanović E, Vučić VM, Arsić A, Nedić O, Sunderić M, Gligorijević N, Milačić D, Isenović ER. Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study. in Canadian Journal of Diabetes. 2020;44(1):22-29.
doi:10.1016/j.jcjd.2019.04.018 .
Resanović, Ivana, Gluvić, Zoran, Zarić, Božidarka, Sudar-Milovanović, Emina, Vučić, Vesna M., Arsić, Aleksandra, Nedić, Olgica, Sunderić, Miloš, Gligorijević, Nikola, Milačić, Davorka, Isenović, Esma R., "Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study" in Canadian Journal of Diabetes, 44, no. 1 (2020):22-29,
https://doi.org/10.1016/j.jcjd.2019.04.018 . .
