Приказ основних података о документу
Adverse plasma fatty acid composition in patients with femoral neck fracture
dc.creator | Arsić, Aleksandra | |
dc.creator | Pešić, Goran | |
dc.creator | Petrović, Snježana | |
dc.creator | Matić, Aleksandar | |
dc.creator | Jeremić, Jovana | |
dc.creator | Jakovljević, Vladimir | |
dc.creator | Vučić, Vesna M. | |
dc.date.accessioned | 2021-04-20T13:08:51Z | |
dc.date.available | 2021-04-20T13:08:51Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0008-4212 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1036 | |
dc.description.abstract | Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-alpha and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-alpha and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered. | en |
dc.publisher | Canadian Science Publishing, Ottawa | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS// | |
dc.rights | restrictedAccess | |
dc.source | Canadian Journal of Physiology & Pharmacology | |
dc.subject | femoral neck fracture | en |
dc.subject | presurgery | en |
dc.subject | postsurgery | en |
dc.subject | fatty acid | en |
dc.subject | arachidonic acid | en |
dc.subject | TNF-alpha | en |
dc.subject | IL-6 | en |
dc.subject | thiobarbituric acid reactive substances | en |
dc.title | Adverse plasma fatty acid composition in patients with femoral neck fracture | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 66 | |
dc.citation.issue | 2 | |
dc.citation.other | 98(2): 61-66 | |
dc.citation.rank | M23~ | |
dc.citation.spage | 61 | |
dc.citation.volume | 98 | |
dc.identifier.doi | 10.1139/cjpp-2019-0249 | |
dc.identifier.pmid | 31491342 | |
dc.identifier.scopus | 2-s2.0-85079202868 | |
dc.identifier.wos | 000514076700003 | |
dc.type.version | publishedVersion |