Endothelial dysfunction in pregnancy metabolic disorders
2020
Аутори
Echeverria, CesarEltit, Felipe
Santibanez, Juan F.
Gatica, Sebastian
Cabello-Verrugio, Claudio
Simon, Felipe
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling... pathways that mediate responses in these pathological conditions.
Кључне речи:
Transporters / Receptors / Endothelial dysfunction / Metabolic disorders / PregnancyИзвор:
Biochimica et Biophysica Acta-Molecular Basis of Disease, 2020, 1866, 2, 165414-Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt 1161288 (FS), 21171566 (SG), 11170840 (CE), and 1161646 (CCV)
- Millennium Institute on Immunology and Immunotherapy [P09-016-F]
- Comision Nacional de Investigacion Cientifica y Tecnologica [CONICYT 21171566]
- Programa de Cooperación Científica ECOS-CONICYT [C16S02]
- BASAL Grant CEDENNA FB0807
- Филогенетски приступ анализи молекуларне еволуције високо варијабилних вируса - коинфекције, интеракција вируса и домаћина (RS-MESTD-Basic Research (BR or ON)-175024)
- Испитивање патогенезе хематолошких малигнитета (RS-MESTD-Basic Research (BR or ON)-175053)
DOI: 10.1016/j.bbadis.2019.02.009
ISSN: 0925-4439
PubMed: 30794867
WoS: 000509614800002
Scopus: 2-s2.0-85062042871
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Echeverria, Cesar AU - Eltit, Felipe AU - Santibanez, Juan F. AU - Gatica, Sebastian AU - Cabello-Verrugio, Claudio AU - Simon, Felipe PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1034 AB - In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions. PB - Elsevier, Amsterdam T2 - Biochimica et Biophysica Acta-Molecular Basis of Disease T1 - Endothelial dysfunction in pregnancy metabolic disorders IS - 2 SP - 165414 VL - 1866 DO - 10.1016/j.bbadis.2019.02.009 ER -
@article{ author = "Echeverria, Cesar and Eltit, Felipe and Santibanez, Juan F. and Gatica, Sebastian and Cabello-Verrugio, Claudio and Simon, Felipe", year = "2020", abstract = "In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.", publisher = "Elsevier, Amsterdam", journal = "Biochimica et Biophysica Acta-Molecular Basis of Disease", title = "Endothelial dysfunction in pregnancy metabolic disorders", number = "2", pages = "165414", volume = "1866", doi = "10.1016/j.bbadis.2019.02.009" }
Echeverria, C., Eltit, F., Santibanez, J. F., Gatica, S., Cabello-Verrugio, C.,& Simon, F.. (2020). Endothelial dysfunction in pregnancy metabolic disorders. in Biochimica et Biophysica Acta-Molecular Basis of Disease Elsevier, Amsterdam., 1866(2), 165414. https://doi.org/10.1016/j.bbadis.2019.02.009
Echeverria C, Eltit F, Santibanez JF, Gatica S, Cabello-Verrugio C, Simon F. Endothelial dysfunction in pregnancy metabolic disorders. in Biochimica et Biophysica Acta-Molecular Basis of Disease. 2020;1866(2):165414. doi:10.1016/j.bbadis.2019.02.009 .
Echeverria, Cesar, Eltit, Felipe, Santibanez, Juan F., Gatica, Sebastian, Cabello-Verrugio, Claudio, Simon, Felipe, "Endothelial dysfunction in pregnancy metabolic disorders" in Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866, no. 2 (2020):165414, https://doi.org/10.1016/j.bbadis.2019.02.009 . .