Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study

2020
Authors
Grabež, MilkicaŠkrbić, Ranko
Stojiljković, Miloš P.
Rudić-Grujić, Vesna
Paunović, Marija P.

Arsić, Aleksandra

Petrović, Snježana B.

Vučić, Vesna M.

Mirjanić-Azarić, Bosa
Savikin, Katarina
Menković, Nebojša
Janković, Teodora
Vasiljević, Nada
Article (Published version)

Metadata
Show full item recordAbstract
Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects... on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.
Keywords:
Pomegranate peel extract / Diabetes mellitus / Lipid profile / Fatty acid / HypertensionSource:
Journal of Functional Foods, 2020, 64, 103692-Publisher:
- Elsevier, Amsterdam
Funding / projects:
- Ministry for Scientific/Technological Development, Higher Education and Information Society, Government of Republic of Srpska
DOI: 10.1016/j.jff.2019.103692
ISSN: 1756-4646
WoS: 000508491000081
Scopus: 2-s2.0-85076606065
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Institut za medicinska istraživanjaTY - JOUR AU - Grabež, Milkica AU - Škrbić, Ranko AU - Stojiljković, Miloš P. AU - Rudić-Grujić, Vesna AU - Paunović, Marija P. AU - Arsić, Aleksandra AU - Petrović, Snježana B. AU - Vučić, Vesna M. AU - Mirjanić-Azarić, Bosa AU - Savikin, Katarina AU - Menković, Nebojša AU - Janković, Teodora AU - Vasiljević, Nada PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1033 AB - Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects on some metabolic parameters, BP, lipid profile and plasma lipid FA composition. PB - Elsevier, Amsterdam T2 - Journal of Functional Foods T1 - Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study SP - 103692 VL - 64 DO - 10.1016/j.jff.2019.103692 ER -
@article{ author = "Grabež, Milkica and Škrbić, Ranko and Stojiljković, Miloš P. and Rudić-Grujić, Vesna and Paunović, Marija P. and Arsić, Aleksandra and Petrović, Snježana B. and Vučić, Vesna M. and Mirjanić-Azarić, Bosa and Savikin, Katarina and Menković, Nebojša and Janković, Teodora and Vasiljević, Nada", year = "2020", abstract = "Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.", publisher = "Elsevier, Amsterdam", journal = "Journal of Functional Foods", title = "Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study", pages = "103692", volume = "64", doi = "10.1016/j.jff.2019.103692" }
Grabež, M., Škrbić, R., Stojiljković, M. P., Rudić-Grujić, V., Paunović, M. P., Arsić, A., Petrović, S. B., Vučić, V. M., Mirjanić-Azarić, B., Savikin, K., Menković, N., Janković, T.,& Vasiljević, N.. (2020). Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. in Journal of Functional Foods Elsevier, Amsterdam., 64, 103692. https://doi.org/10.1016/j.jff.2019.103692
Grabež M, Škrbić R, Stojiljković MP, Rudić-Grujić V, Paunović MP, Arsić A, Petrović SB, Vučić VM, Mirjanić-Azarić B, Savikin K, Menković N, Janković T, Vasiljević N. Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. in Journal of Functional Foods. 2020;64:103692. doi:10.1016/j.jff.2019.103692 .
Grabež, Milkica, Škrbić, Ranko, Stojiljković, Miloš P., Rudić-Grujić, Vesna, Paunović, Marija P., Arsić, Aleksandra, Petrović, Snježana B., Vučić, Vesna M., Mirjanić-Azarić, Bosa, Savikin, Katarina, Menković, Nebojša, Janković, Teodora, Vasiljević, Nada, "Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study" in Journal of Functional Foods, 64 (2020):103692, https://doi.org/10.1016/j.jff.2019.103692 . .