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Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study
Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects... on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.
TY - JOUR
AU - Grabež, Milkica
AU - Škrbić, Ranko
AU - Stojiljković, Miloš P.
AU - Rudić-Grujić, Vesna
AU - Paunović, Marija P.
AU - Arsić, Aleksandra
AU - Petrović, Snježana B.
AU - Vučić, Vesna M.
AU - Mirjanić-Azarić, Bosa
AU - Savikin, Katarina
AU - Menković, Nebojša
AU - Janković, Teodora
AU - Vasiljević, Nada
PY - 2020
UR - http://rimi.imi.bg.ac.rs/handle/123456789/1033
AB - Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.
PB - Elsevier, Amsterdam
T2 - Journal of Functional Foods
T1 - Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study
SP - 103692
VL - 64
DO - 10.1016/j.jff.2019.103692
ER -
@article{
author = "Grabež, Milkica and Škrbić, Ranko and Stojiljković, Miloš P. and Rudić-Grujić, Vesna and Paunović, Marija P. and Arsić, Aleksandra and Petrović, Snježana B. and Vučić, Vesna M. and Mirjanić-Azarić, Bosa and Savikin, Katarina and Menković, Nebojša and Janković, Teodora and Vasiljević, Nada",
year = "2020",
abstract = "Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Functional Foods",
title = "Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study",
pages = "103692",
volume = "64",
doi = "10.1016/j.jff.2019.103692"
}
Grabež, M., Škrbić, R., Stojiljković, M. P., Rudić-Grujić, V., Paunović, M. P., Arsić, A., Petrović, S. B., Vučić, V. M., Mirjanić-Azarić, B., Savikin, K., Menković, N., Janković, T.,& Vasiljević, N.. (2020). Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. in Journal of Functional Foods
Elsevier, Amsterdam., 64, 103692.
https://doi.org/10.1016/j.jff.2019.103692
Grabež M, Škrbić R, Stojiljković MP, Rudić-Grujić V, Paunović MP, Arsić A, Petrović SB, Vučić VM, Mirjanić-Azarić B, Savikin K, Menković N, Janković T, Vasiljević N. Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. in Journal of Functional Foods. 2020;64:103692.
doi:10.1016/j.jff.2019.103692 .
Grabež, Milkica, Škrbić, Ranko, Stojiljković, Miloš P., Rudić-Grujić, Vesna, Paunović, Marija P., Arsić, Aleksandra, Petrović, Snježana B., Vučić, Vesna M., Mirjanić-Azarić, Bosa, Savikin, Katarina, Menković, Nebojša, Janković, Teodora, Vasiljević, Nada, "Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study" in Journal of Functional Foods, 64 (2020):103692,
https://doi.org/10.1016/j.jff.2019.103692 . .
