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dc.creatorVignjević-Petrinović, Sanja
dc.creatorBudeč, Mirela
dc.creatorMarković, Dragana
dc.creatorMitrović-Ajtić, Olivera
dc.creatorJovčić, Gordana
dc.creatorMilošević, Maja
dc.creatorMomčilović, Sanja
dc.creatorČokić, Vladan
dc.date.accessioned2021-04-20T13:08:24Z
dc.date.available2021-04-20T13:08:24Z
dc.date.issued2020
dc.identifier.issn0948-6143
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/1029
dc.description.abstractAnaemia occurs frequently in patients with heart failure and its current treatment lacks clear targets. Emerging evidence suggests that erythroid progenitor cell expansion is an integral part of physiological response to anaemia associated with chronic stress. Understanding the underlying mechanism may provide a novel approach to anaemia management. In this study, we aimed to examine a role for nitric oxide (NO) in the regulation of bone marrow erythroid progenitor response to chronic stress. For this purpose, adult male mice were subjected to 2 h daily restraint stress for 7 or 14 consecutive days. The role of NO was assessed by subcutaneous injection with NG-nitro-l-arginine methyl ester, 30 min prior to each restraint. Chronic exposure to stress resulted in significantly increased number of bone marrow erythroid progenitors, and blockade of NO biosynthesis prior to daily stress completely prevented stress-induced erythroid progenitor cell expansion. Furthermore, chronic stress exposure led to altered expression of neural, endothelial and inducible nitric oxide synthases (NOS) in the bone marrow, both on mRNA and protein level. Decreased expression of neural and endothelial NOS, as well as reduced expression of NF-kappaB/p65 in bone marrow nuclear cell fraction, was accompanied by elevated bone marrow expression of inducible NOS in chronically stressed animals. This is the first study to demonstrate a role for NO in adaptive response of erythroid progenitors to chronic stress. Targeting NO production may be beneficial to improve bone marrow dysfunction and reduced erythroid progenitor cell expansion in chronic heart failure patients.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.rightsrestrictedAccess
dc.sourceHistochemistry & Cell Biology
dc.subjectBone marrowen
dc.subjectErythroid progenitorsen
dc.subjectNitric oxideen
dc.subjectStressen
dc.titleNitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stressen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage468
dc.citation.issue6
dc.citation.other153(6): 457-468
dc.citation.rankaM21~
dc.citation.spage457
dc.citation.volume153
dc.identifier.doi10.1007/s00418-020-01856-y
dc.identifier.pmid32144481
dc.identifier.scopus2-s2.0-85081622035
dc.identifier.wos000518343400001
dc.type.versionpublishedVersion


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