Spatiotemporal gait characteristics of Huntington's disease during dual-task walking
Нема приказа
Аутори
Radovanović, Saša M.Vodopić, Sanja
Stanković, Iva
Dragašević-Mišković, Nataša
Kostić, Vladimir S.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Purpose: Huntington's disease (HD) is an neurodegenerative genetic disorder with characteristic gait changes. HD also results in a range of cognitive impairments, such as difficulties to divide attention, or simultaneously monitoring two tasks. Aim: The impact of cognitive and/or motor tasks on HD gait has not been fully elucidated. The aim was to examine gait in HD patients while performing motor and/or cognitive dual-task walking. Methods: Gait was measured with and without performing concurrent cognitive and/or motor tasks. Sixteen HD patients and 24 healthy control (HC) subjects performed a self-paced basic walking task, a dual motor, a dual mental and a combined motor and mental task while walking. Results: Base walk gait parameters are significantly different between HD and HC groups. Same is true for motor, mental and combined tasks comparisons of HD and HC subjects. Gait velocity is also significantly reduced in HD compared to HC for all experimental conditions. Comparison of b...ase walk and mental task performance showing differences in cycle time, stride length, double support time and CV of stride length, while base walk to motor task comparison is different only in stride length. No differences were found when motor and combined tasks were compared to mental task in HD patients. Conclusion: Gait pattern in HD patients while performing motor and/or cognitive dual tasks walking is remarkably preserved. Gait parameters are changed in order to reduce possible falls, and lack of differences of dual tasks gait parameters variability is attributed that patients minimizing risk of falling and preserving stability.
Кључне речи:
Mental task / cognitive task / GAITRite walkway system / cycle time / falls / fear of fallingИзвор:
International Journal of Neuroscience, 2020, 130, 2, 136-143Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Моторни и немоторни симптоми паркинсонизма: клиничке, морфолошке и молекуларно-генетичке корелације (RS-MESTD-Basic Research (BR or ON)-175090)
DOI: 10.1080/00207454.2019.1667781
ISSN: 0020-7454
PubMed: 31516046
WoS: 000488495200001
Scopus: 2-s2.0-85074048212
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Radovanović, Saša M. AU - Vodopić, Sanja AU - Stanković, Iva AU - Dragašević-Mišković, Nataša AU - Kostić, Vladimir S. PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1023 AB - Purpose: Huntington's disease (HD) is an neurodegenerative genetic disorder with characteristic gait changes. HD also results in a range of cognitive impairments, such as difficulties to divide attention, or simultaneously monitoring two tasks. Aim: The impact of cognitive and/or motor tasks on HD gait has not been fully elucidated. The aim was to examine gait in HD patients while performing motor and/or cognitive dual-task walking. Methods: Gait was measured with and without performing concurrent cognitive and/or motor tasks. Sixteen HD patients and 24 healthy control (HC) subjects performed a self-paced basic walking task, a dual motor, a dual mental and a combined motor and mental task while walking. Results: Base walk gait parameters are significantly different between HD and HC groups. Same is true for motor, mental and combined tasks comparisons of HD and HC subjects. Gait velocity is also significantly reduced in HD compared to HC for all experimental conditions. Comparison of base walk and mental task performance showing differences in cycle time, stride length, double support time and CV of stride length, while base walk to motor task comparison is different only in stride length. No differences were found when motor and combined tasks were compared to mental task in HD patients. Conclusion: Gait pattern in HD patients while performing motor and/or cognitive dual tasks walking is remarkably preserved. Gait parameters are changed in order to reduce possible falls, and lack of differences of dual tasks gait parameters variability is attributed that patients minimizing risk of falling and preserving stability. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Spatiotemporal gait characteristics of Huntington's disease during dual-task walking EP - 143 IS - 2 SP - 136 VL - 130 DO - 10.1080/00207454.2019.1667781 ER -
@article{ author = "Radovanović, Saša M. and Vodopić, Sanja and Stanković, Iva and Dragašević-Mišković, Nataša and Kostić, Vladimir S.", year = "2020", abstract = "Purpose: Huntington's disease (HD) is an neurodegenerative genetic disorder with characteristic gait changes. HD also results in a range of cognitive impairments, such as difficulties to divide attention, or simultaneously monitoring two tasks. Aim: The impact of cognitive and/or motor tasks on HD gait has not been fully elucidated. The aim was to examine gait in HD patients while performing motor and/or cognitive dual-task walking. Methods: Gait was measured with and without performing concurrent cognitive and/or motor tasks. Sixteen HD patients and 24 healthy control (HC) subjects performed a self-paced basic walking task, a dual motor, a dual mental and a combined motor and mental task while walking. Results: Base walk gait parameters are significantly different between HD and HC groups. Same is true for motor, mental and combined tasks comparisons of HD and HC subjects. Gait velocity is also significantly reduced in HD compared to HC for all experimental conditions. Comparison of base walk and mental task performance showing differences in cycle time, stride length, double support time and CV of stride length, while base walk to motor task comparison is different only in stride length. No differences were found when motor and combined tasks were compared to mental task in HD patients. Conclusion: Gait pattern in HD patients while performing motor and/or cognitive dual tasks walking is remarkably preserved. Gait parameters are changed in order to reduce possible falls, and lack of differences of dual tasks gait parameters variability is attributed that patients minimizing risk of falling and preserving stability.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Spatiotemporal gait characteristics of Huntington's disease during dual-task walking", pages = "143-136", number = "2", volume = "130", doi = "10.1080/00207454.2019.1667781" }
Radovanović, S. M., Vodopić, S., Stanković, I., Dragašević-Mišković, N.,& Kostić, V. S.. (2020). Spatiotemporal gait characteristics of Huntington's disease during dual-task walking. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 130(2), 136-143. https://doi.org/10.1080/00207454.2019.1667781
Radovanović SM, Vodopić S, Stanković I, Dragašević-Mišković N, Kostić VS. Spatiotemporal gait characteristics of Huntington's disease during dual-task walking. in International Journal of Neuroscience. 2020;130(2):136-143. doi:10.1080/00207454.2019.1667781 .
Radovanović, Saša M., Vodopić, Sanja, Stanković, Iva, Dragašević-Mišković, Nataša, Kostić, Vladimir S., "Spatiotemporal gait characteristics of Huntington's disease during dual-task walking" in International Journal of Neuroscience, 130, no. 2 (2020):136-143, https://doi.org/10.1080/00207454.2019.1667781 . .