Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies
2020
Аутори
Petrović, SnježanaArsić, Aleksandra
Ristić-Medić, Danijela
Cvetković, Zorica
Vučić, Vesna M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in pat...ients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed.
Кључне речи:
neurodegenerative diseases / lipid peroxidation / antioxidant supplementation / Alzheimer’ / s disease / Parkinson’ / s disease / amyotrophic lateral sclerosisИзвор:
Antioxidants, 2020, 9, 11, 1-27Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
DOI: 10.3390/antiox9111128
ISSN: 2076-3921
PubMed: 33202952
WoS: 000593665800001
Scopus: 2-s2.0-85096058849
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Petrović, Snježana AU - Arsić, Aleksandra AU - Ristić-Medić, Danijela AU - Cvetković, Zorica AU - Vučić, Vesna M. PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1014 AB - Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed. PB - MDPI, Basel T2 - Antioxidants T1 - Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies EP - 27 IS - 11 SP - 1 VL - 9 DO - 10.3390/antiox9111128 ER -
@article{ author = "Petrović, Snježana and Arsić, Aleksandra and Ristić-Medić, Danijela and Cvetković, Zorica and Vučić, Vesna M.", year = "2020", abstract = "Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed.", publisher = "MDPI, Basel", journal = "Antioxidants", title = "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies", pages = "27-1", number = "11", volume = "9", doi = "10.3390/antiox9111128" }
Petrović, S., Arsić, A., Ristić-Medić, D., Cvetković, Z.,& Vučić, V. M.. (2020). Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. in Antioxidants MDPI, Basel., 9(11), 1-27. https://doi.org/10.3390/antiox9111128
Petrović S, Arsić A, Ristić-Medić D, Cvetković Z, Vučić VM. Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. in Antioxidants. 2020;9(11):1-27. doi:10.3390/antiox9111128 .
Petrović, Snježana, Arsić, Aleksandra, Ristić-Medić, Danijela, Cvetković, Zorica, Vučić, Vesna M., "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies" in Antioxidants, 9, no. 11 (2020):1-27, https://doi.org/10.3390/antiox9111128 . .