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Transforming Growth Factor-Beta and Urokinase Type Plasminoge Interplay in Cancer
(Bentham Science Publ Ltd, Sharjah, 2018)
Transforming growth factor-beta (TGF-beta) is well recognized as playing a double role in tumor progression. Its antitumor role takes place in the early stages of cancer development, when TGF-beta acts as a repressor of ...
Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer
(Bentham Science Publ Ltd, Sharjah, 2017)
Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is subject to proteolytic cleavage, which results ...
Novel Patents Targeting Interleukin-17A; Implications in Cancer and Inflammation
(Bentham Science Publ Ltd, Sharjah, 2018)
Background: IL-17A is a founding member of the IL-17 family that has been implicated in the pathogenesis of inflammatory-associated diseases such as cancer and autoimmune disease. In cancer, IL-17A participates in many key ...