Adipogenesis in Different Body Depots and Tumor Development
2020
Authors
Trivanović, DrenkaVignjević-Petrinović, Sanja
Okić Đorđević, Ivana
Kukolj, Tamara
Bugarski, Diana
Jauković, Aleksandra
Article (Published version)
Metadata
Show full item recordAbstract
Adipose tissue (AT) forms depots at different anatomical locations throughout the body, being in subcutaneous and visceral regions, as well as the bone marrow. These ATs differ in the adipocyte functional profile, their insulin sensitivity, adipokines' production, lipolysis, and response to pathologic conditions. Despite the recent advances in lineage tracing, which have demonstrated that individual adipose depots are composed of adipocytes derived from distinct progenitor populations, the cellular and molecular dissection of the adipose clonogenic stem cell niche is still a great challenge. Additional complexity in AT regulation is associated with tumor-induced changes that affect adipocyte phenotype. As an integrative unit of cell differentiation, AT microenvironment regulates various phenotype outcomes of differentiating adipogenic lineages, which consequently may contribute to the neoplastic phenotype manifestations. Particularly interesting is the capacity of AT to impose and supp...ort the aberrant potency of stem cells that accompanies tumor development. In this review, we summarize the current findings on the communication between adipocytes and their progenitors with tumor cells, pointing out to the co-existence of healthy and neoplastic stem cell niches developed during tumor evolution. We also discuss tumor-induced adaptations in mature adipocytes and the involvement of alternative differentiation programs.
Keywords:
adipose tissue depots / adipogenesis / trans-differentiation / tumor / microenvironment / adipose tissue remodeling / stem cell nicheSource:
Frontiers in Cell & Developmental Biology, 2020, 8Publisher:
- Frontiers Media Sa, Lausanne
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)
- Interdisciplinary Center for Clinical Research (IZKF) Wuerzburg, Germany [D-361]
DOI: 10.3389/fcell.2020.571648
ISSN: 2296-634X
PubMed: 33072753
WoS: 000575160000001
Scopus: 2-s2.0-85092064772
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Trivanović, Drenka AU - Vignjević-Petrinović, Sanja AU - Okić Đorđević, Ivana AU - Kukolj, Tamara AU - Bugarski, Diana AU - Jauković, Aleksandra PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/995 AB - Adipose tissue (AT) forms depots at different anatomical locations throughout the body, being in subcutaneous and visceral regions, as well as the bone marrow. These ATs differ in the adipocyte functional profile, their insulin sensitivity, adipokines' production, lipolysis, and response to pathologic conditions. Despite the recent advances in lineage tracing, which have demonstrated that individual adipose depots are composed of adipocytes derived from distinct progenitor populations, the cellular and molecular dissection of the adipose clonogenic stem cell niche is still a great challenge. Additional complexity in AT regulation is associated with tumor-induced changes that affect adipocyte phenotype. As an integrative unit of cell differentiation, AT microenvironment regulates various phenotype outcomes of differentiating adipogenic lineages, which consequently may contribute to the neoplastic phenotype manifestations. Particularly interesting is the capacity of AT to impose and support the aberrant potency of stem cells that accompanies tumor development. In this review, we summarize the current findings on the communication between adipocytes and their progenitors with tumor cells, pointing out to the co-existence of healthy and neoplastic stem cell niches developed during tumor evolution. We also discuss tumor-induced adaptations in mature adipocytes and the involvement of alternative differentiation programs. PB - Frontiers Media Sa, Lausanne T2 - Frontiers in Cell & Developmental Biology T1 - Adipogenesis in Different Body Depots and Tumor Development VL - 8 DO - 10.3389/fcell.2020.571648 ER -
@article{ author = "Trivanović, Drenka and Vignjević-Petrinović, Sanja and Okić Đorđević, Ivana and Kukolj, Tamara and Bugarski, Diana and Jauković, Aleksandra", year = "2020", abstract = "Adipose tissue (AT) forms depots at different anatomical locations throughout the body, being in subcutaneous and visceral regions, as well as the bone marrow. These ATs differ in the adipocyte functional profile, their insulin sensitivity, adipokines' production, lipolysis, and response to pathologic conditions. Despite the recent advances in lineage tracing, which have demonstrated that individual adipose depots are composed of adipocytes derived from distinct progenitor populations, the cellular and molecular dissection of the adipose clonogenic stem cell niche is still a great challenge. Additional complexity in AT regulation is associated with tumor-induced changes that affect adipocyte phenotype. As an integrative unit of cell differentiation, AT microenvironment regulates various phenotype outcomes of differentiating adipogenic lineages, which consequently may contribute to the neoplastic phenotype manifestations. Particularly interesting is the capacity of AT to impose and support the aberrant potency of stem cells that accompanies tumor development. In this review, we summarize the current findings on the communication between adipocytes and their progenitors with tumor cells, pointing out to the co-existence of healthy and neoplastic stem cell niches developed during tumor evolution. We also discuss tumor-induced adaptations in mature adipocytes and the involvement of alternative differentiation programs.", publisher = "Frontiers Media Sa, Lausanne", journal = "Frontiers in Cell & Developmental Biology", title = "Adipogenesis in Different Body Depots and Tumor Development", volume = "8", doi = "10.3389/fcell.2020.571648" }
Trivanović, D., Vignjević-Petrinović, S., Okić Đorđević, I., Kukolj, T., Bugarski, D.,& Jauković, A.. (2020). Adipogenesis in Different Body Depots and Tumor Development. in Frontiers in Cell & Developmental Biology Frontiers Media Sa, Lausanne., 8. https://doi.org/10.3389/fcell.2020.571648
Trivanović D, Vignjević-Petrinović S, Okić Đorđević I, Kukolj T, Bugarski D, Jauković A. Adipogenesis in Different Body Depots and Tumor Development. in Frontiers in Cell & Developmental Biology. 2020;8. doi:10.3389/fcell.2020.571648 .
Trivanović, Drenka, Vignjević-Petrinović, Sanja, Okić Đorđević, Ivana, Kukolj, Tamara, Bugarski, Diana, Jauković, Aleksandra, "Adipogenesis in Different Body Depots and Tumor Development" in Frontiers in Cell & Developmental Biology, 8 (2020), https://doi.org/10.3389/fcell.2020.571648 . .