Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk
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2019
Аутори
Pokimica, Biljana![](/themes/MirageRIMI/images/orcid.png)
Garcia-Conesa, Maria-Teresa
Zec, Manja M.
![](/themes/MirageRIMI/images/orcid.png)
Debeljak-Martačić, Jasmina
![](/themes/MirageRIMI/images/orcid.png)
Ranković, Slavica G.
![](/themes/MirageRIMI/images/orcid.png)
Vidović, Nevena Đ.
![](/themes/MirageRIMI/images/orcid.png)
Petrović-Oggiano, Gordana P.
![](/themes/MirageRIMI/images/orcid.png)
Konić-Ristić, Aleksandra
![](/themes/MirageRIMI/images/orcid.png)
Glibetić, Marija
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Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the place...bo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition.
Кључне речи:
Aronia / anthocyanins / polyphenols / obesity / hyperlipidemia / blood pressure / SFA / n-6 PUFA / palmitic acid / cardiovascular risk factorsИзвор:
Nutrients, 2019, 11, 4Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans (EU-FP7-312090)
- COST action [FA1403—POSITIVe], Interindividual variation in response to consumption of plant food bioactives and determinants involved
DOI: 10.3390/nu11040850
ISSN: 2072-6643
PubMed: 30991718
WoS: 000467749800143
Scopus: 2-s2.0-85064965417
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Pokimica, Biljana AU - Garcia-Conesa, Maria-Teresa AU - Zec, Manja M. AU - Debeljak-Martačić, Jasmina AU - Ranković, Slavica G. AU - Vidović, Nevena Đ. AU - Petrović-Oggiano, Gordana P. AU - Konić-Ristić, Aleksandra AU - Glibetić, Marija PY - 2019 UR - http://rimi.imi.bg.ac.rs/handle/123456789/977 AB - Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition. PB - MDPI, Basel T2 - Nutrients T1 - Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk IS - 4 VL - 11 DO - 10.3390/nu11040850 ER -
@article{ author = "Pokimica, Biljana and Garcia-Conesa, Maria-Teresa and Zec, Manja M. and Debeljak-Martačić, Jasmina and Ranković, Slavica G. and Vidović, Nevena Đ. and Petrović-Oggiano, Gordana P. and Konić-Ristić, Aleksandra and Glibetić, Marija", year = "2019", abstract = "Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition.", publisher = "MDPI, Basel", journal = "Nutrients", title = "Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk", number = "4", volume = "11", doi = "10.3390/nu11040850" }
Pokimica, B., Garcia-Conesa, M., Zec, M. M., Debeljak-Martačić, J., Ranković, S. G., Vidović, N. Đ., Petrović-Oggiano, G. P., Konić-Ristić, A.,& Glibetić, M.. (2019). Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk. in Nutrients MDPI, Basel., 11(4). https://doi.org/10.3390/nu11040850
Pokimica B, Garcia-Conesa M, Zec MM, Debeljak-Martačić J, Ranković SG, Vidović NĐ, Petrović-Oggiano GP, Konić-Ristić A, Glibetić M. Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk. in Nutrients. 2019;11(4). doi:10.3390/nu11040850 .
Pokimica, Biljana, Garcia-Conesa, Maria-Teresa, Zec, Manja M., Debeljak-Martačić, Jasmina, Ranković, Slavica G., Vidović, Nevena Đ., Petrović-Oggiano, Gordana P., Konić-Ristić, Aleksandra, Glibetić, Marija, "Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk" in Nutrients, 11, no. 4 (2019), https://doi.org/10.3390/nu11040850 . .