Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies
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Kardum, Nevena Đ.Konić-Ristić, Aleksandra
Zec, Manja M.
Kojadinović, Milica
Petrović-Oggiano, Gordana P.
Zeković, Milica
Kroon, Paul A.
Glibetić, Marija
Article (Published version)
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Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in human...s.
Keywords:
Aronia melanocarpa / anthocyanins / platelet function / functional food / bioactivesSource:
International Journal of Food Sciences & Nutrition, 2017, 68, 6, 742-749Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- European Commission, EU Seventh Framework Programme (FP7) [2312090]
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- UK Research & Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/F/00044434, BBS/E/F/00042675]
DOI: 10.1080/09637486.2017.1283682
ISSN: 0963-7486
PubMed: 28147889
WoS: 000404871700011
Scopus: 2-s2.0-85011690499
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Institut za medicinska istraživanjaTY - JOUR AU - Kardum, Nevena Đ. AU - Konić-Ristić, Aleksandra AU - Zec, Manja M. AU - Kojadinović, Milica AU - Petrović-Oggiano, Gordana P. AU - Zeković, Milica AU - Kroon, Paul A. AU - Glibetić, Marija PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/782 AB - Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in humans. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Food Sciences & Nutrition T1 - Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies EP - 749 IS - 6 SP - 742 VL - 68 DO - 10.1080/09637486.2017.1283682 ER -
@article{ author = "Kardum, Nevena Đ. and Konić-Ristić, Aleksandra and Zec, Manja M. and Kojadinović, Milica and Petrović-Oggiano, Gordana P. and Zeković, Milica and Kroon, Paul A. and Glibetić, Marija", year = "2017", abstract = "Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in humans.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Food Sciences & Nutrition", title = "Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies", pages = "749-742", number = "6", volume = "68", doi = "10.1080/09637486.2017.1283682" }
Kardum, N. Đ., Konić-Ristić, A., Zec, M. M., Kojadinović, M., Petrović-Oggiano, G. P., Zeković, M., Kroon, P. A.,& Glibetić, M.. (2017). Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies. in International Journal of Food Sciences & Nutrition Taylor & Francis Ltd, Abingdon., 68(6), 742-749. https://doi.org/10.1080/09637486.2017.1283682
Kardum NĐ, Konić-Ristić A, Zec MM, Kojadinović M, Petrović-Oggiano GP, Zeković M, Kroon PA, Glibetić M. Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies. in International Journal of Food Sciences & Nutrition. 2017;68(6):742-749. doi:10.1080/09637486.2017.1283682 .
Kardum, Nevena Đ., Konić-Ristić, Aleksandra, Zec, Manja M., Kojadinović, Milica, Petrović-Oggiano, Gordana P., Zeković, Milica, Kroon, Paul A., Glibetić, Marija, "Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies" in International Journal of Food Sciences & Nutrition, 68, no. 6 (2017):742-749, https://doi.org/10.1080/09637486.2017.1283682 . .