Gait in drug naive patients with de novo Parkinson's disease - altered but symmetric
Abstract
Background: Motor symptoms in Parkinson's disease (PD) are typically asymmetrical. Early stage of PD is characterised with a predominantly unilateral appearance of tremor, rigidity and bradykinesia, with or without axial involvement. Also, studies have demonstrated gait asymmetry in de novo drug naive PD patients. Aim of this study was to investigate gait pattern, gait symmetry and gait variability in early phases of PD. Methods: The gait was measured in 40 de novo, drug naive PD patients and 43 healthy control subjects (HC) while performing a simple walking task. Calculated parameters were cycle time (CT), stride length (SL) and swing time (ST), and their coefficients of variation (CV). Results: Considering gait parameters, PD patients and HC differed in terms of all parameters, except for the CV of CT. Analysis of gait symmetry, comparison between the gait patterns of the left and the right leg in PD patients revealed no difference for any of the assessed parameters. The majority of ...the gait parameters did not differ between left and right legs of HC. Conclusions: It can be concluded that even gait was already altered in de novo drug naive PD patients, gait symmetry remained preserved. The SL was the most prominent parameter of altered gait in initial stages of PD patients, while the ST heralded postural asymmetry.
Keywords:
Gait symmetry / Gait cycle / Stride length / de novo Parkinson's disease / HY scaleSource:
Neurological Research, 2015, 37, 8, 712-716Publisher:
- Maney Publishing, Leeds
Funding / projects:
- Motor and non-motor symptoms and signs in parkinsonism: clinical, morphological and molecular-genetic correlates (RS-MESTD-Basic Research (BR or ON)-175090)
DOI: 10.1179/1743132815Y.0000000043
ISSN: 0161-6412
PubMed: 25916791
WoS: 000356891600008
Scopus: 2-s2.0-84933510404
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Grajić, Mirko AU - Stanković, Iva AU - Radovanović, Saša M. AU - Kostić, Vladimir S. PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/678 AB - Background: Motor symptoms in Parkinson's disease (PD) are typically asymmetrical. Early stage of PD is characterised with a predominantly unilateral appearance of tremor, rigidity and bradykinesia, with or without axial involvement. Also, studies have demonstrated gait asymmetry in de novo drug naive PD patients. Aim of this study was to investigate gait pattern, gait symmetry and gait variability in early phases of PD. Methods: The gait was measured in 40 de novo, drug naive PD patients and 43 healthy control subjects (HC) while performing a simple walking task. Calculated parameters were cycle time (CT), stride length (SL) and swing time (ST), and their coefficients of variation (CV). Results: Considering gait parameters, PD patients and HC differed in terms of all parameters, except for the CV of CT. Analysis of gait symmetry, comparison between the gait patterns of the left and the right leg in PD patients revealed no difference for any of the assessed parameters. The majority of the gait parameters did not differ between left and right legs of HC. Conclusions: It can be concluded that even gait was already altered in de novo drug naive PD patients, gait symmetry remained preserved. The SL was the most prominent parameter of altered gait in initial stages of PD patients, while the ST heralded postural asymmetry. PB - Maney Publishing, Leeds T2 - Neurological Research T1 - Gait in drug naive patients with de novo Parkinson's disease - altered but symmetric EP - 716 IS - 8 SP - 712 VL - 37 DO - 10.1179/1743132815Y.0000000043 ER -
@article{ author = "Grajić, Mirko and Stanković, Iva and Radovanović, Saša M. and Kostić, Vladimir S.", year = "2015", abstract = "Background: Motor symptoms in Parkinson's disease (PD) are typically asymmetrical. Early stage of PD is characterised with a predominantly unilateral appearance of tremor, rigidity and bradykinesia, with or without axial involvement. Also, studies have demonstrated gait asymmetry in de novo drug naive PD patients. Aim of this study was to investigate gait pattern, gait symmetry and gait variability in early phases of PD. Methods: The gait was measured in 40 de novo, drug naive PD patients and 43 healthy control subjects (HC) while performing a simple walking task. Calculated parameters were cycle time (CT), stride length (SL) and swing time (ST), and their coefficients of variation (CV). Results: Considering gait parameters, PD patients and HC differed in terms of all parameters, except for the CV of CT. Analysis of gait symmetry, comparison between the gait patterns of the left and the right leg in PD patients revealed no difference for any of the assessed parameters. The majority of the gait parameters did not differ between left and right legs of HC. Conclusions: It can be concluded that even gait was already altered in de novo drug naive PD patients, gait symmetry remained preserved. The SL was the most prominent parameter of altered gait in initial stages of PD patients, while the ST heralded postural asymmetry.", publisher = "Maney Publishing, Leeds", journal = "Neurological Research", title = "Gait in drug naive patients with de novo Parkinson's disease - altered but symmetric", pages = "716-712", number = "8", volume = "37", doi = "10.1179/1743132815Y.0000000043" }
Grajić, M., Stanković, I., Radovanović, S. M.,& Kostić, V. S.. (2015). Gait in drug naive patients with de novo Parkinson's disease - altered but symmetric. in Neurological Research Maney Publishing, Leeds., 37(8), 712-716. https://doi.org/10.1179/1743132815Y.0000000043
Grajić M, Stanković I, Radovanović SM, Kostić VS. Gait in drug naive patients with de novo Parkinson's disease - altered but symmetric. in Neurological Research. 2015;37(8):712-716. doi:10.1179/1743132815Y.0000000043 .
Grajić, Mirko, Stanković, Iva, Radovanović, Saša M., Kostić, Vladimir S., "Gait in drug naive patients with de novo Parkinson's disease - altered but symmetric" in Neurological Research, 37, no. 8 (2015):712-716, https://doi.org/10.1179/1743132815Y.0000000043 . .