Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats
2015
Authors
Miloradović, ZoranMihailović-Stanojević, Nevena
Jovović, Đurđica
Ivanov, Milan
Vajić, Una Jovana
Karanović, Danijela
Grujić-Milanović, Jelica
Article (Published version)
Metadata
Show full item recordAbstract
Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular... resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.
Keywords:
Vibroacustic microvibrations / Experimental hypertension / Oxidative stressSource:
General Physiology & Biophysics, 2015, 34, 1, 89-94Publisher:
- General Physiol And Biophysics, Bratislava
Funding / projects:
- Investigation of antihypertensiv? and renoprotectiv? potential of natural and synthetic compounds in the experimental models of cardiovascular and renal diseases (RS-MESTD-Basic Research (BR or ON)-175096)
DOI: 10.4149/gpb_2014033
ISSN: 0231-5882
PubMed: 25395600
WoS: 000349585000011
Scopus: 2-s2.0-84925359374
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Miloradović, Zoran AU - Mihailović-Stanojević, Nevena AU - Jovović, Đurđica AU - Ivanov, Milan AU - Vajić, Una Jovana AU - Karanović, Danijela AU - Grujić-Milanović, Jelica PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/656 AB - Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals. PB - General Physiol And Biophysics, Bratislava T2 - General Physiology & Biophysics T1 - Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats EP - 94 IS - 1 SP - 89 VL - 34 DO - 10.4149/gpb_2014033 ER -
@article{ author = "Miloradović, Zoran and Mihailović-Stanojević, Nevena and Jovović, Đurđica and Ivanov, Milan and Vajić, Una Jovana and Karanović, Danijela and Grujić-Milanović, Jelica", year = "2015", abstract = "Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.", publisher = "General Physiol And Biophysics, Bratislava", journal = "General Physiology & Biophysics", title = "Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats", pages = "94-89", number = "1", volume = "34", doi = "10.4149/gpb_2014033" }
Miloradović, Z., Mihailović-Stanojević, N., Jovović, Đ., Ivanov, M., Vajić, U. J., Karanović, D.,& Grujić-Milanović, J.. (2015). Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats. in General Physiology & Biophysics General Physiol And Biophysics, Bratislava., 34(1), 89-94. https://doi.org/10.4149/gpb_2014033
Miloradović Z, Mihailović-Stanojević N, Jovović Đ, Ivanov M, Vajić UJ, Karanović D, Grujić-Milanović J. Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats. in General Physiology & Biophysics. 2015;34(1):89-94. doi:10.4149/gpb_2014033 .
Miloradović, Zoran, Mihailović-Stanojević, Nevena, Jovović, Đurđica, Ivanov, Milan, Vajić, Una Jovana, Karanović, Danijela, Grujić-Milanović, Jelica, "Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats" in General Physiology & Biophysics, 34, no. 1 (2015):89-94, https://doi.org/10.4149/gpb_2014033 . .