Transcranial Application of Near-Infrared Low-Level Laser Can Modulate Cortical Excitability
Само за регистроване кориснике
2013
Аутори
Konstantinović, LjubicaJelić, Milan
Jeremić, Aleksandra
Stevanović, Vuk
Milanović, Slađan
Filipović, Saša
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background and Objective: Near-infrared low-level laser (NIR-LLL) irradiation penetrates scalp and skull and can reach superficial layers of the cerebral cortex. It was shown to improve the outcome of acute stroke in both animal and human studies. In this study we evaluated whether transcranial laser stimulation (TLS) with NIR-LLL can modulate the excitability of the motor cortex (M1) as measured by transcranial magnetic stimulation (TMS). Methods: TLS was applied for 5 minutes over the representation of the right first dorsal interosseal muscle (FDI) in left primary motor cortex (M1), in 14 healthy subjects. Motor evoked potentials (MEPs) from the FDI, elicited by single-pulse TMS, were measured at baseline and up to 30 minutes after the TLS. Results: The average MEP size was significantly reduced during the first 20 minutes following the TLS. The pattern was present in 10(71.5%) of the participants. The MEP size reduction correlated negatively with the motor threshold at rest. Conclu...sions: TLS with NIR-LLL induced transitory reduction of the excitability of the stimulated cortex. These findings give further insights into the mechanisms of TLS effects in the human cerebral cortex, paving the way for potential applications of TLS in treatment of stroke and in other clinical settings. Lasers Surg. Med. 45:648-653, 2013.
Кључне речи:
neuronal excitability / membrane potential / transcranial magnetic stimulation / photobiomodulation / humanИзвор:
Lasers in Surgery & Medicine, 2013, 45, 10, 648-653Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
- Неинвазивна модулација кортикалне ексцитабилности и пластицитета - Развој метода неинвазивне неуромодулације централног нервног система у испитивања физиолошких механизама, дијагностици и терапији (RS-MESTD-Basic Research (BR or ON)-175012)
DOI: 10.1002/lsm.22190
ISSN: 0196-8092
PubMed: 24136303
WoS: 000328348400005
Scopus: 2-s2.0-84890529667
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Konstantinović, Ljubica AU - Jelić, Milan AU - Jeremić, Aleksandra AU - Stevanović, Vuk AU - Milanović, Slađan AU - Filipović, Saša PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/477 AB - Background and Objective: Near-infrared low-level laser (NIR-LLL) irradiation penetrates scalp and skull and can reach superficial layers of the cerebral cortex. It was shown to improve the outcome of acute stroke in both animal and human studies. In this study we evaluated whether transcranial laser stimulation (TLS) with NIR-LLL can modulate the excitability of the motor cortex (M1) as measured by transcranial magnetic stimulation (TMS). Methods: TLS was applied for 5 minutes over the representation of the right first dorsal interosseal muscle (FDI) in left primary motor cortex (M1), in 14 healthy subjects. Motor evoked potentials (MEPs) from the FDI, elicited by single-pulse TMS, were measured at baseline and up to 30 minutes after the TLS. Results: The average MEP size was significantly reduced during the first 20 minutes following the TLS. The pattern was present in 10(71.5%) of the participants. The MEP size reduction correlated negatively with the motor threshold at rest. Conclusions: TLS with NIR-LLL induced transitory reduction of the excitability of the stimulated cortex. These findings give further insights into the mechanisms of TLS effects in the human cerebral cortex, paving the way for potential applications of TLS in treatment of stroke and in other clinical settings. Lasers Surg. Med. 45:648-653, 2013. PB - Wiley-Blackwell, Hoboken T2 - Lasers in Surgery & Medicine T1 - Transcranial Application of Near-Infrared Low-Level Laser Can Modulate Cortical Excitability EP - 653 IS - 10 SP - 648 VL - 45 DO - 10.1002/lsm.22190 ER -
@article{ author = "Konstantinović, Ljubica and Jelić, Milan and Jeremić, Aleksandra and Stevanović, Vuk and Milanović, Slađan and Filipović, Saša", year = "2013", abstract = "Background and Objective: Near-infrared low-level laser (NIR-LLL) irradiation penetrates scalp and skull and can reach superficial layers of the cerebral cortex. It was shown to improve the outcome of acute stroke in both animal and human studies. In this study we evaluated whether transcranial laser stimulation (TLS) with NIR-LLL can modulate the excitability of the motor cortex (M1) as measured by transcranial magnetic stimulation (TMS). Methods: TLS was applied for 5 minutes over the representation of the right first dorsal interosseal muscle (FDI) in left primary motor cortex (M1), in 14 healthy subjects. Motor evoked potentials (MEPs) from the FDI, elicited by single-pulse TMS, were measured at baseline and up to 30 minutes after the TLS. Results: The average MEP size was significantly reduced during the first 20 minutes following the TLS. The pattern was present in 10(71.5%) of the participants. The MEP size reduction correlated negatively with the motor threshold at rest. Conclusions: TLS with NIR-LLL induced transitory reduction of the excitability of the stimulated cortex. These findings give further insights into the mechanisms of TLS effects in the human cerebral cortex, paving the way for potential applications of TLS in treatment of stroke and in other clinical settings. Lasers Surg. Med. 45:648-653, 2013.", publisher = "Wiley-Blackwell, Hoboken", journal = "Lasers in Surgery & Medicine", title = "Transcranial Application of Near-Infrared Low-Level Laser Can Modulate Cortical Excitability", pages = "653-648", number = "10", volume = "45", doi = "10.1002/lsm.22190" }
Konstantinović, L., Jelić, M., Jeremić, A., Stevanović, V., Milanović, S.,& Filipović, S.. (2013). Transcranial Application of Near-Infrared Low-Level Laser Can Modulate Cortical Excitability. in Lasers in Surgery & Medicine Wiley-Blackwell, Hoboken., 45(10), 648-653. https://doi.org/10.1002/lsm.22190
Konstantinović L, Jelić M, Jeremić A, Stevanović V, Milanović S, Filipović S. Transcranial Application of Near-Infrared Low-Level Laser Can Modulate Cortical Excitability. in Lasers in Surgery & Medicine. 2013;45(10):648-653. doi:10.1002/lsm.22190 .
Konstantinović, Ljubica, Jelić, Milan, Jeremić, Aleksandra, Stevanović, Vuk, Milanović, Slađan, Filipović, Saša, "Transcranial Application of Near-Infrared Low-Level Laser Can Modulate Cortical Excitability" in Lasers in Surgery & Medicine, 45, no. 10 (2013):648-653, https://doi.org/10.1002/lsm.22190 . .