Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study
2013
Authors
Ristić-Medić, DanijelaTakić, Marija
Vučić, Vesna M.
Kandić, Dragoslav
Kostić, Nada
Glibetić, Marija
Article (Published version)
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Show full item recordAbstract
The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. Total n-6 and n-3 polyunsaturated fatty acids (PUFA), and levels of linoleic, dihomo-gama linolenic, arachidonic, and docosahexaenoic acid were significantly lower (p lt 0.001) in patients with alcoholic cirrhosis compared to healthy controls. Significant changes were also found between patients stratified according to nutritional status. In particular, the sum of n-3 PUFA was significantly lower (p lt 0.001) and ratio of n-6/n-3 fatty acids was higher (p lt 0.01) in malnourished patients when compared to the patients with acceptable nutritional status. Furthermore, important changes in the levels of saturated fatty acids, palmitoleic and oleic... acid and long-chain PUFA were found in wellnourished patients with alcoholic cirrhosis as well. Our present data confirmed evidence that malnutrition is one of the factors that led to lower levels of polyunsaturated fatty acids in patients with alcoholic liver cirrhosis. PUFA supplementation in the latter needs further investigation.
Keywords:
phospholipids fatty acid / alcohol / cirrhosis / malnutritionSource:
Journal of Clinical Biochemistry & Nutrition, 2013, 53, 1, 49-54Publisher:
- Journal Clinical Biochemistry & Nutrition, Kyoto
Funding / projects:
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
DOI: 10.3164/jcbn.12-79
ISSN: 0912-0009
PubMed: 23874070
WoS: 000330146900008
Scopus: 2-s2.0-84881290962
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Institut za medicinska istraživanjaTY - JOUR AU - Ristić-Medić, Danijela AU - Takić, Marija AU - Vučić, Vesna M. AU - Kandić, Dragoslav AU - Kostić, Nada AU - Glibetić, Marija PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/476 AB - The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. Total n-6 and n-3 polyunsaturated fatty acids (PUFA), and levels of linoleic, dihomo-gama linolenic, arachidonic, and docosahexaenoic acid were significantly lower (p lt 0.001) in patients with alcoholic cirrhosis compared to healthy controls. Significant changes were also found between patients stratified according to nutritional status. In particular, the sum of n-3 PUFA was significantly lower (p lt 0.001) and ratio of n-6/n-3 fatty acids was higher (p lt 0.01) in malnourished patients when compared to the patients with acceptable nutritional status. Furthermore, important changes in the levels of saturated fatty acids, palmitoleic and oleic acid and long-chain PUFA were found in wellnourished patients with alcoholic cirrhosis as well. Our present data confirmed evidence that malnutrition is one of the factors that led to lower levels of polyunsaturated fatty acids in patients with alcoholic liver cirrhosis. PUFA supplementation in the latter needs further investigation. PB - Journal Clinical Biochemistry & Nutrition, Kyoto T2 - Journal of Clinical Biochemistry & Nutrition T1 - Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study EP - 54 IS - 1 SP - 49 VL - 53 DO - 10.3164/jcbn.12-79 ER -
@article{ author = "Ristić-Medić, Danijela and Takić, Marija and Vučić, Vesna M. and Kandić, Dragoslav and Kostić, Nada and Glibetić, Marija", year = "2013", abstract = "The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. Total n-6 and n-3 polyunsaturated fatty acids (PUFA), and levels of linoleic, dihomo-gama linolenic, arachidonic, and docosahexaenoic acid were significantly lower (p lt 0.001) in patients with alcoholic cirrhosis compared to healthy controls. Significant changes were also found between patients stratified according to nutritional status. In particular, the sum of n-3 PUFA was significantly lower (p lt 0.001) and ratio of n-6/n-3 fatty acids was higher (p lt 0.01) in malnourished patients when compared to the patients with acceptable nutritional status. Furthermore, important changes in the levels of saturated fatty acids, palmitoleic and oleic acid and long-chain PUFA were found in wellnourished patients with alcoholic cirrhosis as well. Our present data confirmed evidence that malnutrition is one of the factors that led to lower levels of polyunsaturated fatty acids in patients with alcoholic liver cirrhosis. PUFA supplementation in the latter needs further investigation.", publisher = "Journal Clinical Biochemistry & Nutrition, Kyoto", journal = "Journal of Clinical Biochemistry & Nutrition", title = "Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study", pages = "54-49", number = "1", volume = "53", doi = "10.3164/jcbn.12-79" }
Ristić-Medić, D., Takić, M., Vučić, V. M., Kandić, D., Kostić, N.,& Glibetić, M.. (2013). Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study. in Journal of Clinical Biochemistry & Nutrition Journal Clinical Biochemistry & Nutrition, Kyoto., 53(1), 49-54. https://doi.org/10.3164/jcbn.12-79
Ristić-Medić D, Takić M, Vučić VM, Kandić D, Kostić N, Glibetić M. Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study. in Journal of Clinical Biochemistry & Nutrition. 2013;53(1):49-54. doi:10.3164/jcbn.12-79 .
Ristić-Medić, Danijela, Takić, Marija, Vučić, Vesna M., Kandić, Dragoslav, Kostić, Nada, Glibetić, Marija, "Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study" in Journal of Clinical Biochemistry & Nutrition, 53, no. 1 (2013):49-54, https://doi.org/10.3164/jcbn.12-79 . .