Erythrocytes as a novel drug delivery systems: Current status, challenges and perspectives of medical applications
Eritrociti kao savremeni nosači lekovitih supstanci - trenutni status, izazovi i izgledi za primenu u medicini
Апстракт
The erythrocytes are the most abundant cellular components ( gt 99%) of blood in humans. Besides their well known physiological functions, they serve as a natural blood compartment participating in biodistribution, metabolism and action of certain drugs. On the other hand, the erythrocytes possess potential carrier capabilities and can be used for the controlled and targeted delivery of various bioactive compounds, including peptides and genetic materials. The erythrocytes feature some unique advantages compared to other delivery systems, such as high biocompatibility, biodegradability, long lifespan, remarkable decrease in concentration fluctuations in steady state in comparison to the conventional methods of drug administration etc. This short review accentuate the most significant experimental results and perspectives of medical applications of novel drug delivery systems based on erythrocytes. .
Eritrociti predstavljaju najzastupljenije ćelijske komponente krvi ( gt 99%) kod ljudi. Pored dobro poznatih fizioloških funkcija koje vrše, oni predstavljaju i prirodne kompartmane krvi koje učestvuju u biodistribuciji, metabolizmu i delovanju određenih lekovitih supstanci. S druge strane, eritrociti poseduju ogroman potencijal kao nosači za kontrolisanu i ciljanu isporuku različitih bioaktivnih jedinjenja, uključujući i peptide i genetički materijal. Produženi životni vek u cirkulaciji, dostupnost, visoka biokompatibilnost i prirodni mehanizmi za bezbednu eliminaciju, kao i značajno smanjenje fluktuacije koncentracije lekovite supstance u plazmi, čine jedinstvene prednosti eritrocita kao nosača lekovitih supstanci u poređenju sa konvencionalnim načinima administracije lekova. Ovaj kratki pregled ističe najznačajnije eksperimentalne rezultate i izglede za primenu eritrocita kao savremenih nosača lekovitih supstanci u medicini. .
Кључне речи:
erythrocytes / carrier / intravascular drug delivery / targeting RES organs / eritrociti / nosači lekovitih supstanci / intravaskularno dejstvo / ciljanje organa RESИзвор:
MD - Medical data, 2012, 4, 3, 287-292Издавач:
- MOST ART d.o.o., Beograd
Институција/група
Institut za medicinska istraživanjaKostić, I., Ilić, V.,& Bugarski, B.. (2012). Erythrocytes as a novel drug delivery systems: Current status, challenges and perspectives of medical applications. in MD - Medical data MOST ART d.o.o., Beograd., 4(3), 287-292. https://hdl.handle.net/21.15107/rcub_technorep_2063
Kostić I, Ilić V, Bugarski B. Erythrocytes as a novel drug delivery systems: Current status, challenges and perspectives of medical applications. in MD - Medical data. 2012;4(3):287-292. https://hdl.handle.net/21.15107/rcub_technorep_2063 .
Kostić, Ivana, Ilić, Vesna, Bugarski, Branko, "Erythrocytes as a novel drug delivery systems: Current status, challenges and perspectives of medical applications" in MD - Medical data, 4, no. 3 (2012):287-292, https://hdl.handle.net/21.15107/rcub_technorep_2063 .