Granulopoiesis during acute Toxoplasma gondii infection in mice
Нема приказа
Аутори
Jovčić, GordanaPetakov, Marijana
Bugarski, Diana
Đurković-Đaković, Olgica
Kragujević, A
Stojanović, N.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There is little evidence for the role of granulocytes in the host defence against the protozoan parasite Toxoplasma gondii. Thus, the purpose of this study was to assess the involvement of granulocytes during acute murine infection with the parasite virulent RH strain. Since, all infected animals succumb to infection in a dose-dependent period of time, the effect of two parasite doses, 2x10(2) and 2x10(6), on granulocytis cell compartments in the bone marrow and peripheral blood up to 2 or 6 days post infection, respectively, was investigated. The data obtained revealed that granulocytic cells at various stages of differentiation and maturation were affected by T.gondii infection regardless of the dose applied. The observed oscillating changes in the number of cells in granulocytic proliferative and nonproliferative compartments imply that parallel with T.gondii-induced damage to granulocytic cells, a process of stimulated production of granulocytes occurred. Although some differences ...in the kinetics of cellular changes and in the extent of cell damage were found similar reactivity patterns of granulocytic cells were seen following infection with both doses. Our results demonstrated significant changes in granulopoiesis during T.gondii infection, suggesting a possible contribution of granulocytes to parasite control.
Кључне речи:
Toxoplasma gondii / acute infection / mice / granulocytesИзвор:
Acta Veterinaria-Beograd, 1997, 47, 5-6, 313-320Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Jovčić, Gordana AU - Petakov, Marijana AU - Bugarski, Diana AU - Đurković-Đaković, Olgica AU - Kragujević, A AU - Stojanović, N. PY - 1997 UR - http://rimi.imi.bg.ac.rs/handle/123456789/33 AB - There is little evidence for the role of granulocytes in the host defence against the protozoan parasite Toxoplasma gondii. Thus, the purpose of this study was to assess the involvement of granulocytes during acute murine infection with the parasite virulent RH strain. Since, all infected animals succumb to infection in a dose-dependent period of time, the effect of two parasite doses, 2x10(2) and 2x10(6), on granulocytis cell compartments in the bone marrow and peripheral blood up to 2 or 6 days post infection, respectively, was investigated. The data obtained revealed that granulocytic cells at various stages of differentiation and maturation were affected by T.gondii infection regardless of the dose applied. The observed oscillating changes in the number of cells in granulocytic proliferative and nonproliferative compartments imply that parallel with T.gondii-induced damage to granulocytic cells, a process of stimulated production of granulocytes occurred. Although some differences in the kinetics of cellular changes and in the extent of cell damage were found similar reactivity patterns of granulocytic cells were seen following infection with both doses. Our results demonstrated significant changes in granulopoiesis during T.gondii infection, suggesting a possible contribution of granulocytes to parasite control. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Granulopoiesis during acute Toxoplasma gondii infection in mice EP - 320 IS - 5-6 SP - 313 VL - 47 UR - https://hdl.handle.net/21.15107/rcub_rimi_33 ER -
@article{ author = "Jovčić, Gordana and Petakov, Marijana and Bugarski, Diana and Đurković-Đaković, Olgica and Kragujević, A and Stojanović, N.", year = "1997", abstract = "There is little evidence for the role of granulocytes in the host defence against the protozoan parasite Toxoplasma gondii. Thus, the purpose of this study was to assess the involvement of granulocytes during acute murine infection with the parasite virulent RH strain. Since, all infected animals succumb to infection in a dose-dependent period of time, the effect of two parasite doses, 2x10(2) and 2x10(6), on granulocytis cell compartments in the bone marrow and peripheral blood up to 2 or 6 days post infection, respectively, was investigated. The data obtained revealed that granulocytic cells at various stages of differentiation and maturation were affected by T.gondii infection regardless of the dose applied. The observed oscillating changes in the number of cells in granulocytic proliferative and nonproliferative compartments imply that parallel with T.gondii-induced damage to granulocytic cells, a process of stimulated production of granulocytes occurred. Although some differences in the kinetics of cellular changes and in the extent of cell damage were found similar reactivity patterns of granulocytic cells were seen following infection with both doses. Our results demonstrated significant changes in granulopoiesis during T.gondii infection, suggesting a possible contribution of granulocytes to parasite control.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Granulopoiesis during acute Toxoplasma gondii infection in mice", pages = "320-313", number = "5-6", volume = "47", url = "https://hdl.handle.net/21.15107/rcub_rimi_33" }
Jovčić, G., Petakov, M., Bugarski, D., Đurković-Đaković, O., Kragujević, A.,& Stojanović, N.. (1997). Granulopoiesis during acute Toxoplasma gondii infection in mice. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 47(5-6), 313-320. https://hdl.handle.net/21.15107/rcub_rimi_33
Jovčić G, Petakov M, Bugarski D, Đurković-Đaković O, Kragujević A, Stojanović N. Granulopoiesis during acute Toxoplasma gondii infection in mice. in Acta Veterinaria-Beograd. 1997;47(5-6):313-320. https://hdl.handle.net/21.15107/rcub_rimi_33 .
Jovčić, Gordana, Petakov, Marijana, Bugarski, Diana, Đurković-Đaković, Olgica, Kragujević, A, Stojanović, N., "Granulopoiesis during acute Toxoplasma gondii infection in mice" in Acta Veterinaria-Beograd, 47, no. 5-6 (1997):313-320, https://hdl.handle.net/21.15107/rcub_rimi_33 .