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p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells
dc.creator | Krstić, Aleksandra | |
dc.creator | Ilić, Vesna | |
dc.creator | Mojsilović, Slavko | |
dc.creator | Jovčić, Gordana | |
dc.creator | Milenković, Pavle B. | |
dc.creator | Bugarski, Diana | |
dc.date.accessioned | 2021-04-20T12:17:36Z | |
dc.date.available | 2021-04-20T12:17:36Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0897-7194 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/242 | |
dc.description.abstract | The effects of interleukin (IL)-17 on nitric oxide (NO) synthase (NOS) expression, as well as the participation of mitogen-activated protein kinases (MAPKs) in IL-17-mediated effects were examined in murine bone marrow cells. The results demonstrated the ability of IL-17 to upregulate the expression of mRNA for both inducible NOS and constitutive, endothelial NOS isoforms, as well as to enhance the phosphorylation of p38 MAPK. Moreover, both the NOS-inducing effect of IL-17 and the in vitro IL-17-mediated inhibition colony forming unit-erythroid (CFU-E) growth were dependent on p38 MAPK activity. The data demonstrating that the in vivo reducing effect of IL-17 on bone marrow CFU-E was prevented by co-treatment with the NOS inhibitor Nw-nitro-l-arginine methyl ester hydrochloride (L-NAME), implied that this effect is mediated through NOS activation. Besides revealing a link between the IL-17, NO, and haematopoiesis, data presented gave an insight into the mechanisms by which IL-17 exerts its modulatory effects on bone marrow cells. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145048/RS// | |
dc.rights | restrictedAccess | |
dc.source | Growth Factors | |
dc.subject | IL-17 | en |
dc.subject | NOS | en |
dc.subject | MAPK | en |
dc.subject | CFU-E | en |
dc.subject | bone marrow | en |
dc.title | p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 90 | |
dc.citation.issue | 2 | |
dc.citation.other | 27(2): 79-90 | |
dc.citation.rank | M22 | |
dc.citation.spage | 79 | |
dc.citation.volume | 27 | |
dc.identifier.doi | 10.1080/08977190902757153 | |
dc.identifier.pmid | 19204843 | |
dc.identifier.scopus | 2-s2.0-66949146946 | |
dc.identifier.wos | 000264098800002 | |
dc.type.version | publishedVersion |
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