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The metabolic syndrome, an epidemic among HIV-infected patients on HAART
dc.creator | Jevtović, Đorđe | |
dc.creator | Dragović, G. | |
dc.creator | Salemović, Dubravka | |
dc.creator | Ranin, Jovan | |
dc.creator | Đurković-Đaković, Olgica | |
dc.date.accessioned | 2021-04-20T12:17:28Z | |
dc.date.available | 2021-04-20T12:17:28Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/240 | |
dc.description.abstract | Background: HAART has dramatically changed the prognosis of AIDS, but has led to long-term toxicities of antiretroviral drugs. A major chronic complication is the metabolic syndrome (MS), including hyperlipidemia, lipodystrophy (LD), and impaired glucose metabolism. Methods: A cross-sectional study of a series of 582 patients from the Serbian HIV/AIDS cohort, treated with HAART for a mean period of 3.3 +/- 2.1 years (range 1-10), was performed to evaluate the prevalence and risk factors for MS during HAART. Results: The prevalence of LID was 29.1%, with a 100% probability of development after 10 years of treatment. Risk factors for LD included female gender(OR 1.7, 95% CI 1.0-2.7, P = 0.02), age gt 40 (OR 1.7,95% CI 1.1-2.7, P = 0.01) and AIDS at HAART initiation (OR 1.9,95% CI 1.2-2.2, P lt 0.01), as well as prolonged usage of NRTIs (OR 2.7, 95% CI 1.6-4.5, P lt 0.01). The NNRTI-based regimens were less likely to induce LD than those PI-based (OR 1.87, 95% CI 1.2-2.9 vs. OR 3.7, 95% CI 2.3-6.1, respectively). Hyperlipidemia occurred in 47% of the patients, and was associated with male gender (OR 2.2, 95% CI 1.4-3.5, P lt 0.01) and prolonged usage of PI + NNRTI HAART (OR 3.0, 95% CI 1.8-4.9, P lt 0.01). In contrast, regimens composed of 2 NRTI + NNRTI were less likely to induce hyperlipidemia (OR 0.4, 95% CI 0.3-0.7, P = 0.03). Glucose intolerance and/or diabetes mellitus was recorded in 9.6%, if with AIDS at HAART initiation (OR 3.7, 95% CI 1.2-11.4, P lt 0.01), male gender (OR 5.2, 95% CI 1.8-15.1, P lt 0.01) and age gt 40 (OR 2.6, 95% CI 1.1-6.3, P = 0.02). Conclusion: MS seems an inevitable consequence of long-term successful HAART. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145002/RS// | |
dc.rights | restrictedAccess | |
dc.source | Biomedicine & Pharmacotherapy | |
dc.subject | HIV | en |
dc.subject | HAART | en |
dc.subject | Metabolic syndrome (MS) | en |
dc.title | The metabolic syndrome, an epidemic among HIV-infected patients on HAART | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 342 | |
dc.citation.issue | 5 | |
dc.citation.other | 63(5): 337-342 | |
dc.citation.rank | M22 | |
dc.citation.spage | 337 | |
dc.citation.volume | 63 | |
dc.identifier.doi | 10.1016/j.biopha.2008.09.011 | |
dc.identifier.pmid | 18996676 | |
dc.identifier.scopus | 2-s2.0-68749122041 | |
dc.identifier.wos | 000266901900029 | |
dc.type.version | publishedVersion |