The efficacy of two protocols for inducing motor cortex plasticity in healthy humans - TMS study
Nema prikaza
Autori
Ilić, Nela V.Sajić, Jelena
Migković, Melanija
Krstić, Jelena
Milanović, Slađan
![](/themes/MirageRIMI/images/orcid.png)
Vesović-Potić, Vladislava
Ljubisavljević, Miloš
![](/themes/MirageRIMI/images/orcid.png)
Ilić, Tihomir V.
![](/themes/MirageRIMI/images/orcid.png)
Članak u časopisu (Objavljena verzija)
![](/themes/MirageRIMI//images/creativecommons/arr.png)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Stimulation-induced plasticity represents an experimental model of motor cortex reorganization. It can be produced in awaked humans by combining the non-invasive electrical stimulation of somatosensory afferents via mixed peripheral nerves with the transcranial magnetic stimulation (TMS) of the motor cortex. Animal experiments indicate that an application of two converging inputs from various sources in a tightly coupled manner, following the so called Hebbian rule of learning, leads to an increase in motor cortical excitability. The aim of our study was to compare the effects of two plasticity-inducing protocols by quantifying the motor cortex changes using TMS. Plasticity was induced by combining peripheral nerve stimulation with TMS (paired associative stimulation - PAS) and by peripheral motor point stimulation of two adjacent hand muscles (dual associative stimulation - DAS). The protocols were randomly applied in 12 right-handed healthy volunteers. The amplitudes of TMS-induced m...otor-evoked potentials (MEPs) in the right abductor pollicis brevis muscle were recorded before, immediately after PAS or DAS stimulation, and 10, 20 and 30 min later. Both protocols led to significant and lasting changes in MEP amplitudes, however, a significantly larger increase in MEPs was observed after PAS than DAS. The results indicate that afferent input can differently affect cortical motor circuits and produce variable motor output. Thus, the efficacy of LTP-like mechanisms, presumably involved in Hebbian-like plasticity in humans, varies with the types/origin of the converging inputs. Our findings may be relevant when designing therapeutic interventions for improving motor function after neurological injury or disease.
Ključne reči:
Transcranial magnetic stimulation / Paired associative stimulation / Motor cortex plasticity / HumansIzvor:
General Physiology & Biophysics, 2009, 28, 228-234Izdavač:
- General Physiol And Biophysics, Bratislava
Finansiranje / projekti:
- Kortikalna ekscitabilnost i plasticitet kod zdravih ispitanika i pacijenata obolelih od poremećaja motorike – neurofiziološka ispitivanja mehanizama nastanka, mogućnosti modulacije, funkcionalnog i terapijskog značaja (RS-MESTD-MPN2006-2010-145083)
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Ilić, Nela V. AU - Sajić, Jelena AU - Migković, Melanija AU - Krstić, Jelena AU - Milanović, Slađan AU - Vesović-Potić, Vladislava AU - Ljubisavljević, Miloš AU - Ilić, Tihomir V. PY - 2009 UR - http://rimi.imi.bg.ac.rs/handle/123456789/233 AB - Stimulation-induced plasticity represents an experimental model of motor cortex reorganization. It can be produced in awaked humans by combining the non-invasive electrical stimulation of somatosensory afferents via mixed peripheral nerves with the transcranial magnetic stimulation (TMS) of the motor cortex. Animal experiments indicate that an application of two converging inputs from various sources in a tightly coupled manner, following the so called Hebbian rule of learning, leads to an increase in motor cortical excitability. The aim of our study was to compare the effects of two plasticity-inducing protocols by quantifying the motor cortex changes using TMS. Plasticity was induced by combining peripheral nerve stimulation with TMS (paired associative stimulation - PAS) and by peripheral motor point stimulation of two adjacent hand muscles (dual associative stimulation - DAS). The protocols were randomly applied in 12 right-handed healthy volunteers. The amplitudes of TMS-induced motor-evoked potentials (MEPs) in the right abductor pollicis brevis muscle were recorded before, immediately after PAS or DAS stimulation, and 10, 20 and 30 min later. Both protocols led to significant and lasting changes in MEP amplitudes, however, a significantly larger increase in MEPs was observed after PAS than DAS. The results indicate that afferent input can differently affect cortical motor circuits and produce variable motor output. Thus, the efficacy of LTP-like mechanisms, presumably involved in Hebbian-like plasticity in humans, varies with the types/origin of the converging inputs. Our findings may be relevant when designing therapeutic interventions for improving motor function after neurological injury or disease. PB - General Physiol And Biophysics, Bratislava T2 - General Physiology & Biophysics T1 - The efficacy of two protocols for inducing motor cortex plasticity in healthy humans - TMS study EP - 234 SP - 228 VL - 28 UR - https://hdl.handle.net/21.15107/rcub_rimi_233 ER -
@article{ author = "Ilić, Nela V. and Sajić, Jelena and Migković, Melanija and Krstić, Jelena and Milanović, Slađan and Vesović-Potić, Vladislava and Ljubisavljević, Miloš and Ilić, Tihomir V.", year = "2009", abstract = "Stimulation-induced plasticity represents an experimental model of motor cortex reorganization. It can be produced in awaked humans by combining the non-invasive electrical stimulation of somatosensory afferents via mixed peripheral nerves with the transcranial magnetic stimulation (TMS) of the motor cortex. Animal experiments indicate that an application of two converging inputs from various sources in a tightly coupled manner, following the so called Hebbian rule of learning, leads to an increase in motor cortical excitability. The aim of our study was to compare the effects of two plasticity-inducing protocols by quantifying the motor cortex changes using TMS. Plasticity was induced by combining peripheral nerve stimulation with TMS (paired associative stimulation - PAS) and by peripheral motor point stimulation of two adjacent hand muscles (dual associative stimulation - DAS). The protocols were randomly applied in 12 right-handed healthy volunteers. The amplitudes of TMS-induced motor-evoked potentials (MEPs) in the right abductor pollicis brevis muscle were recorded before, immediately after PAS or DAS stimulation, and 10, 20 and 30 min later. Both protocols led to significant and lasting changes in MEP amplitudes, however, a significantly larger increase in MEPs was observed after PAS than DAS. The results indicate that afferent input can differently affect cortical motor circuits and produce variable motor output. Thus, the efficacy of LTP-like mechanisms, presumably involved in Hebbian-like plasticity in humans, varies with the types/origin of the converging inputs. Our findings may be relevant when designing therapeutic interventions for improving motor function after neurological injury or disease.", publisher = "General Physiol And Biophysics, Bratislava", journal = "General Physiology & Biophysics", title = "The efficacy of two protocols for inducing motor cortex plasticity in healthy humans - TMS study", pages = "234-228", volume = "28", url = "https://hdl.handle.net/21.15107/rcub_rimi_233" }
Ilić, N. V., Sajić, J., Migković, M., Krstić, J., Milanović, S., Vesović-Potić, V., Ljubisavljević, M.,& Ilić, T. V.. (2009). The efficacy of two protocols for inducing motor cortex plasticity in healthy humans - TMS study. in General Physiology & Biophysics General Physiol And Biophysics, Bratislava., 28, 228-234. https://hdl.handle.net/21.15107/rcub_rimi_233
Ilić NV, Sajić J, Migković M, Krstić J, Milanović S, Vesović-Potić V, Ljubisavljević M, Ilić TV. The efficacy of two protocols for inducing motor cortex plasticity in healthy humans - TMS study. in General Physiology & Biophysics. 2009;28:228-234. https://hdl.handle.net/21.15107/rcub_rimi_233 .
Ilić, Nela V., Sajić, Jelena, Migković, Melanija, Krstić, Jelena, Milanović, Slađan, Vesović-Potić, Vladislava, Ljubisavljević, Miloš, Ilić, Tihomir V., "The efficacy of two protocols for inducing motor cortex plasticity in healthy humans - TMS study" in General Physiology & Biophysics, 28 (2009):228-234, https://hdl.handle.net/21.15107/rcub_rimi_233 .